wild-type

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wild type

Genetics
adjective Referring to an organism or gene locus that predominates in natural or normal populations.

noun The normal condition of a whole organism (wild-type strain) or a particular mutation at a locus or site, which is indicated by a plus sign. The allele of a particular gene that confers the phenotype considered to be the "normal" type commonly found in natural populations. Because some DNA sequence polymorphisms do not produce different phenotypes, there can be multiple "wild-type" alleles of a gene.

Molecular biology
noun The naturally occurring phenotype of an organism; a strain of organism used as a standard reference with which to compare mutant derivatives.

wild-type

(wīld′tīp″)

Pert. to the genotype or phenotype that predominates in a species in nature.

wild type

References in periodicals archive ?

We performed plaque-forming assay in vitro and compared viral plaques between wild-type and I529T MERS-CoV.

Sequential Emergence and Wide Spread of Neutralization Escape Middle East Respiratory Syndrome Coronavirus Mutants, South Korea, 2015

Administration of hydroprednisone significantly decreased IFN-a, TNF-a, IL-6, IL-13 , and IL-4 mRNA expression levels in wild-type asthmatic group ( P < 0.05), but not in GLCCI1 -/- asthmatic group (except for IFN-a and TNF-a, P < 0.05).

Effects of Glucocorticoid-Induced Transcript 1 Gene Deficiency on Glucocorticoid Activation in Asthmatic Mice

An example of a SD-OCT B-Scan image acquired in a wild-type mouse is shown in Figure 1(a).

Assessment of Global and Local Alterations in Retinal Layer Thickness in Ins2 (Akita) Diabetic Mice by Spectral Domain Optical Coherence Tomography

Myo3a mutant mice and wild-type mice were anesthetized using pentobarbital sodium and perfused with 4% PFA.

Knock-In Mice with Myo3a Y137C Mutation Displayed Progressive Hearing Loss and Hair Cell Degeneration in the Inner Ear

Initial clinical development of H3B-6545 will target breast cancer patients with wild-type and mutant ER?

H3 Biomedicine Preclinical Studies Show Selective Estrogen Receptor Covalent Antagonist Inactivates Wild-type and Mutant Estrogen Receptor Alphas

We initially assessed the lower limit of detection of our assay by serial dilution of mutant cell line gDNA (initially measured at 160.4 Ng/[micro]L via a fluorospectrometer (Thermo Fisher), calculated to represent 47000 copies/[micro]L) into wild-type cell line gDNA (initially measured at 120.9 ng/uL, calculated to represent 35 000 copies/[micro]L).

Single-Nucleotide Polymorphism Leading to False Allelic Fraction by Droplet Digital PCR

In 2016, Mandel et al.10 analyzed their institutional data and found statistically significant improvement in median OS in patients with mutated IDH1 compared to wild-type IDH1 (83 versus 22 months; p < 0.0001).

Prognostic significance of IDH 1 mutation in patients with glioblastoma multiforme

In 6-month-old animals, wild-type and [CathA.sup.S190A] mice showed a parallel learning pattern but a different learning pace.

Mice with Catalytically Inactive Cathepsin A Display Neurobehavioral Alterations

For induction of type 1 diabetic mouse model, 8-weekold male wild-type and Nrf2-KO mice were injected with multiple low-dose streptozotocin (Sigma-Aldrich, St.

Prevention of Streptozotocin-Induced Diabetic Nephropathy by MG132: Possible Roles of Nrf2 and I[kappa]B

The threshold of the wild-type MscS was constantly ~0.6 when the membrane (cytoplasmic) potential was scanned between -100 and +40 mV (Figure 2(b)).

Voltage-Dependent Inactivation of MscS Occurs Independently of the Positively Charged Residues in the Transmembrane Domain

elegans wild-type and mutant strains using CM-[H.sub.2]DCFDA, following a previously described method (22) with minor modifications.

Rosmarinus officinalis L. increases Caenorhabditis elegans stress resistance and longevity in a DAF-16, HSF-1 and SKN-1-dependent manner

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