wild-type

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wild-type

(wīld´tīp) that occurring in a natural population or in the standard laboratory stock, as a strain, phenotype, or gene, and therefore designated as representative of the group.

wild type

Genetics
adjective Referring to an organism or gene locus that predominates in natural or normal populations.

noun The normal condition of a whole organism (wild-type strain) or a particular mutation at a locus or site, which is indicated by a plus sign. The allele of a particular gene that confers the phenotype considered to be the "normal" type commonly found in natural populations. Because some DNA sequence polymorphisms do not produce different phenotypes, there can be multiple "wild-type" alleles of a gene.

Molecular biology
noun The naturally occurring phenotype of an organism; a strain of organism used as a standard reference with which to compare mutant derivatives.

wild-type

(wīld′tīp″)

Pert. to the genotype or phenotype that predominates in a species in nature.

wild type

References in periodicals archive ?

Initial clinical development of H3B-6545 will target breast cancer patients with wild-type and mutant ER?

H3 Biomedicine Preclinical Studies Show Selective Estrogen Receptor Covalent Antagonist Inactivates Wild-type and Mutant Estrogen Receptor Alphas

8 RNA copies/reaction for vaccine and wild-type YFV strains (online Technical Appendix Figure 3).

Lineage-Specific Real-Time Reverse Transcription PCR for Yellow Fever Virus Outbreak Surveillance, Brazil

10 analyzed their institutional data and found statistically significant improvement in median OS in patients with mutated IDH1 compared to wild-type IDH1 (83 versus 22 months; p < 0.

Prognostic significance of IDH 1 mutation in patients with glioblastoma multiforme

We first evaluated the performance of the hydrolysis probe targeting the EZH2 Y641F mutation using an assay that lacked a probe targeting the wild-type allele on DNA from a cell line heterozygous for that mutation.

Multiplex Droplet Digital PCR Quantification of Recurrent Somatic Mutations in Diffuse Large B-Cell and Follicular Lymphoma

The results of the TAILOR study further reaffirm that Erbitux plus FOLFOX as chemotherapy backbone is an effective treatment regimen for patients with RAS wild-type mCRC, as we have seen in previous international pivotal studies, such as OPUS, said Prof.

Germany : Results of Pivotal TAILOR Study Confirm Addition of Erbitux to FOLFOX Significantly Improves Outcomes in RAS Wild-Type Metastatic Colorectal Cancer

We found that patients with wild-type KRAS who received EGFR-inhibitor targeted therapy such as cetuximab or panitumumab showed improved survival, as reflected by their median survival of 72 months," their retrospective study noted.

Mutated Gene Influencing Metastatic Colorectal Cancer Survival Rate, According to PiscoMed's Journal AMOR

DELTA]tolC, wild-type, and [DELTA]tolC+ were processed and observed via scanning electron microscopy (SEM) (Yuen et al.

Role of TolC in virulence of salmonella enterica serovar Typhi

The LPS caused a significant fall in systolic blood pressure from 3 to 24 h, and a significant decrease in heart rate from 9 to 24 h in wild-type and SPAK knockout mice [Figure 1]a and [Figure 1]b.

Role of sterile 20/sps1-related proline/alanine-rich kinase in mice with endotoxic shock

3mg/kg) in the wild-type and the MPO deficient mice induced acute airway inflammation, characterized by an increase of the lung lavage cell numbers.

Lung Neutrophilia in Myeloperoxidase Deficient Mice during the Course of Acute Pulmonary Inflammation

001) increase in confirmed objective response rate--the study's primary endpoint--in patients with BRAF wild-type melanoma treated with the Opdivo +Yervoy Regimen (60%) compared to those treated with Yervoy monotherapy (11%).

Bristol-Myers Squibb Co. received approval from the FDA for Opdivo (nivolumab) in combination with Yervoy (ipilimumab), for the treatment of patients with BRAFV600 wild-type unresectable or metastatic melanoma

A sensory evaluation undertaken by a panel of 81 untrained consumers revealed no significant difference in the liking of color or texture among the samples containing the CHI, Del and ROS1 genes, and wild-type tomatoes.

Transgenics yields tomatoes with high flavonoid content

The trial enrolled a total of 418 patients with treatment naive BRAF wild-type unresectable Stage III and IV melanoma and they were given either Opdivo 3mg/kg every two weeks or dacarbazine 1000mg/m2 every three weeks.