(redirected from whitefish)
Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.

calcitonin (salmon)

APO-Calcitonin, Calcimar, Caltine, Fortical, Miacalcic (UK), Miacalcin, Miacalcin Nasal Spray, Sandoz Calcitonin

Pharmacologic class: Hormone (calcium-lowering)

Therapeutic class: Hypocalcemic

Pregnancy risk category C


Directly affects bone, kidney, and GI tract. Decreases osteoclastic osteolysis in bone; also reduces mineral release and collagen breakdown in bone and promotes renal excretion of calcium. In pain relief, acts through prostaglandin inhibition, pain threshold modification, or beta-endorphin stimulation.


Injection: 0.5 mg/ml (human), 1 mg/ml (human), 200 international units/ml in 2-ml vials (salmon)

Nasal spray (salmon): 200 international units/actuation, metered nasal spray in 3.7 ml-bottle

Indications and dosages

Postmenopausal osteoporosis

Adults: Calcitonin (salmon)-100 international units/day I.M. or subcutaneously, or 200 international units/day intranasally with concurrent supplemental calcium and vitamin D

Paget's disease of bone (osteitis deformans)

Adults: Calcitonin (salmon)-Initially, 100 international units/day I.M. or subcutaneously; after titration, maintenance dosage is 50 to 100 international units daily or every other day (three times weekly). Calcitonin (human)-0.5 mg I.M. or subcutaneously daily, reduced to 0.25 mg daily.


Adults: Calcitonin (salmon)-4 international units/kg I.M. or subcutaneously q 12 hours; after 1 or 2 days, may increase to 8 international units/kg q 12 hours; after 2 more days, may increase further, if needed, to 8 international units q 6 hours.


• Hypersensitivity to drug or salmon

• Pregnancy or breastfeeding


Use cautiously in:

• renal insufficiency, pernicious anemia

• children.


Before salmon calcitonin therapy begins, perform skin test, if prescribed. Don't give drug if patient has positive reaction. Have epinephrine available.

• Bring nasal spray to room temperature before using.

• Give intranasal dose as one spray in one nostril daily; alternate nostrils every day.

• To minimize adverse effects, give at bedtime.

• Rotate injection sites to decrease inflammatory reactions.

Adverse reactions

CNS: headache, weakness, dizziness, paresthesia

CV: chest pain

EENT: epistaxis, nasal irritation, rhinitis

GI: nausea, vomiting, diarrhea, epigastric pain or discomfort

GU: urinary frequency

Musculoskeletal: arthralgia, back pain

Respiratory: dyspnea

Skin: rash

Other: altered taste, allergic reactions including facial flushing, swelling, and anaphylaxis


Drug-drug. Previous use of bisphosphonates (alendronate, etidronate, pamidronate, risedronate): decreased response to calcitonin

Patient monitoring

• Monitor for adverse reactions during first few days of therapy.

• Assess alkaline phosphatase level and 24-hour urinary excretion of hydroxyproline.

• Check urine for casts.

• Monitor serum electrolyte and calcium levels.

Patient teaching

• Instruct patient to take drug before bedtime to lessen GI upset. Tell him to call prescriber if he can't maintain his usual diet because of GI upset.

• Inform patient using nasal spray that runny nose, sneezing, and nasal irritation may occur during first several days as he adjusts to spray.

• Instruct patient to bring nasal spray to room temperature before using.

• Advise patient to blow nose before using spray, to take intranasal dose as one spray in one nostril daily, and to alternate nostrils with each dose.

• Tell patient to discard unrefrigerated bottles of calcitonin (salmon) nasal spray after 30 days.

• Encourage patient to consume a diet rich in calcium and vitamin D.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved
Relating to mucocutaneous lesions with a ‘salmon’ colour
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
During this short period when growth is possible (July-August), whitefish have to eat and accumulate enough energy for spawning at December before surviving the long and severe winter.
In 2017, a Whitefish Strategic Housing Plan was completed, which included a strategy to convert short-term rentals back into long-term housing.
"On lakes like Clearwater, on the other hand, with fewer whitefish and no burbot, pre-baiting is a necessity.
This need for redundancy was highlighted by the recent temporary outages, which had nothing to do with Whitefish Energy's completed work on those energised lines.
In a follow-up post, Anglin called on his followers to target Whitefish businesses and organizations he claims are supporting the "Jewish extortion racket," including the Montana Human Rights Network, which is affiliated with Love Lives Here, the Chamber of Commerce and several elected officials.
Preserved tissue samples from multiple infected Mountain Whitefish (Prosopium williamsoni) from the Missouri River, Montana, were identified by individuals at Oregon State University.
On appeal, Whitefish argued that a hearing to determine the fair market value of foreclosed property is not required by statute.
Typically, scales have been used to estimate age of Pygmy Whitefish (Weisel and Dillon, 1954; Eschmeyer and Bailey, 1955; Heard and Hartman, 1966; McCart, 1965; Weisel et al., 1973; Barnett and Paige, 2014), although otoliths have been used more recendy (McPhail and Zemlak, 2001; Zemlak and McPhail, 2004; Plumb, 2006; Sullivan, 2011).
To date, CLAC and Whitefish have partnered to deliver three pre-employment construction and pre-employment scaffold training programs in the community.
White of the Folsom attempted to turn toward the shelter of Whitefish Bay, the Nelsons towline snapped, and the ice-laden ship slipped beneath the waves.
The Agriculture Minister has admitted he is "frustrated" at the EU's decision to slash quotas of whitefish by up to 64%.
-- A shortage of whitefish in the Great Lakes region resulting partly from the winter deep freeze is coming at an inconvenient time for Jewish families: the Passover holiday, when demand is high because it's a key ingredient in a traditional recipe.