One of the reasons we're so fat, the research suggests, is because the regions of the genome that help turn white fat
to brown were essentially locked up -- tucked away and closed for business -- in humans but not in chimps.
Animal studies have now demonstrated that quercetin--either alone or in combination with resveratrol--can convert white fat
cells into those resembling brown fat cells.
"Exercise can also boost Irisin levels to turn white fat
into brown fat," he said.
According to the study, after the needles degrade the drug molecules, they slowly diffuse to the energy-storing white fat
underneath the skin layer, to turn them into energy-burning brown fats that are found in babies.
The origin of the beige adipocyte is complex; some beige adipocytes arise in epididymal white fat
from precursors that express platelet-derived growth factor receptor alpha PDGFRa, cD34, and spinocerebellar ataxia type 1 (SCA1) proteins [29-34].
The low melting point of white fat
allows deer to mobilize stored energy very quickly.
Professor Min Du, at Washington State University, said: "They convert white fat
into beige fat which burns off lipids (fats), helping to keep the body in balance, and prevent obesity and metabolic dysfunction."
A genetic variant tightly linked to obesity causes fat-precursor cells to become energy-storing white fat
instead of energy-burning beige fat, researchers report online August 19 in the New England Journal of Medicine.
The brown/beige markers P2RX5 and PAT2 were detected in the carotid sheath and longus colli areas around the neck, where thermogenic fat cells are present, whereas the white fat
cell marker ASC-1 was much more prominent in the subcutaneous and omental fat depots, both of which predominantly consist of white adipocytes.
ISLAMABAD -- Scientists have discovered a molecular pathway called mTORC1 that controls the conversion of unhealthy white fat
into beige fat.
The white fat
cells store fat, while brown fat cells actually increase combustion of fat.
In the current study, male offspring (i.e., the F1 generation) of mice exposed to TBT during pregnancy showed marked increases in the number and size of white fat
cells and significant but less pronounced increases in the weight of white fat
deposits (or "depots") around the kidney and under the skin.