Wheal-and-flare reaction | definition of wheal-and-flare reaction by Medical dictionary
Also found in: Acronyms
the characteristic immediate reaction observed in an allergy skin test; within 10-15 minutes after injection of antigen (allergen), an irregular, blanched, elevated wheal appears, surrounded by an area of erythema (flare).
wheal-and-flare reaction Triple response of Lewis Immunology A series of 3 sequential responses that occur in skin subjected to minor trauma, caused by tissue release of histamine; WFR tests immediate hypersensitivity–'reaginic' or allergic reaction to an antigen, and can be transferred to a nonallergic person. See P-K test.
wheal-and-er·y·the·ma re·ac·tion (wēl er'i-thē'mă rē-ak'shŭn)
The characteristic immediate reaction observed in the skin test; within 10-15 minutes after injection of antigen (allergen), an irregular, blanched, elevated wheal appears, surrounded by an area of erythema (flare).
Synonym(s): wheal-and-flare reaction
References in periodicals archive
As serum and plasma do not differ in their autoantibody content, this observation points to a possible role of clotting factors in wheal-and-flare reaction
. It has been reasoned that plasma contains more coagulation factors and complement, while consumption of such factors in serum during formation of clot is responsible for the discrepant reactivity of autologous plasma and serum.
Similar rapid onset of action and magnitude of effect of fexofenadine and cetirizine as assessed by inhibition of histamine-induced wheal-and-flare reaction
. Ann Allergy Asthma Immunol 2004:93:562-67.
The stinger is a modified ovapositor with a venom gland.[6,11] Almost all persons stung will develop a wheal-and-flare reaction
, which resolves within 30 minutes to 1 hour. This thin evolves into a sterile pustule at the site of the sting within 24 hours.
induced by allergen and histamine: Evaluation of blood flow with laser Doppler flowmetry.