well-differentiated liposarcoma


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well-differentiated liposarcoma

A well-circumscribed, slow-growing, low-grade malignancy of fat cells, which arises de novo (i.e., not from pre-existing lipomas) in deep soft tissue of thighs, retroperitoneum, and groin of middle-aged adults. As a general rule, the deeper the tumour, the more likely it is to recur.

Epidemiology
5000 new cases/year (US), which is 20% of all soft-tissue tumours; average age 50, slightly more common in males.

Clinical findings
Mass, history of trauma, swelling, reduced range of motion, increased varicose veins, fatigue, abdominal pain, nausea, vomiting, weight loss, compartment syndrome.
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References in periodicals archive ?
Well-differentiated liposarcoma of the retroperitoneum: a clinicopathologic analysis of 20 cases, with particular attention to the extent of low-grade dedifferentiation.
Dedifferentiated Liposarcoma With Myofibroblastic Differentiation
Malignant transformation of a benign lipoma to malignant liposarcoma is practically unknown.8 It is crucial that the diagnosis of a well-differentiated liposarcoma is established preoperatively, because there are differences in initial treatment, longterm management and prognosis.
Laparoscopic resection of large pelvic lipoma causing obstructive uropathy in a 66 year old female - A case report from Greece
(4) The incidence of liposarcoma in the hypopharynx is not well-reported in the literature, with less than 40 cases reported, almost all of which are well-differentiated liposarcoma. (5,6)
Dedifferentiated liposarcoma of the hypolarynx
The value of fat-suppressed T2 or STIR sequences in distinguishing lipoma from well-differentiated liposarcoma. Eur Radiol.
Clinical presentation, diagnostic approach, and treatment of hand lipomas: a review
CT appearance of a well-differentiated liposarcoma may be very similar to the remnants of infiltrated soft tissue [10].
Intramuscular (Infiltrating) Lipoma of the Floor of the Mouth
Eward et al., "Can experienced observers differentiate between lipoma and well-differentiated liposarcoma using only MRI?," Sarcoma, vol.
The Value of MRI in Distinguishing Subtypes of Lipomatous Extremity Tumors Needs Reassessment in the Era of MDM2 and CDK4 Testing
Caption: Figure 3: Histology of the primary site-dedifferentiated liposarcoma (a, b) and well-differentiated liposarcoma components (c, d) and the metastasis (e, f).
Spinal Metastasis of Well-Differentiated Liposarcoma Component in Retroperitoneal Dedifferentiated Liposarcoma Treated by Minimally Invasive Surgery
It is noteworthy that imaging features of lipomas can be similar to well-differentiated liposarcomas. Presence of imaging features such as thick enhancing septa, presence of nodular and/or globular, or nonadipose mass like areas and decreased percentage of fat within the lesion are suggestive of malignancy [7].
Trans Arterial Embolization of Spontaneous Intra-Abdominal Haemorrhage from Omental Lipoma
The histopathologic exam showed a well-differentiated liposarcoma with spindle and lipoma-like cells (Grade 1), without infiltration of the testis and with free surgical margins.
Multidisciplinary approach to giant paratesticular liposarcoma
Common types of liposarcoma include well-differentiated liposarcoma, myxoid, dedifferentiated, and pleomorphic liposarcoma.
Liposarcoma Pipeline Overview - Combination of Radiation Therapy and Surgeries to Gain Demand
One case each of malignant fibrous histiocytoma, myxoid liposarcoma [Figure 1b], atypical lipomatous tumor/ well-differentiated liposarcoma (ALT/WDL), and malignant mesothelioma were identified.
Histopathological spectrum of tumor and tumor-like lesions of the paratestis in a tertiary care hospital
[sup][4] Liposarcomas were divided into the following five subtypes: well-differentiated liposarcoma, dedifferentiated liposarcoma, myxoid liposarcoma, pleomorphic liposarcoma, and mixed liposarcoma.
Prognostic Factors Predicting the Postoperative Survival Period Following Treatment for Primary Retroperitoneal Liposarcoma

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