of the retroperitoneum: a clinicopathologic analysis of 20 cases, with particular attention to the extent of low-grade dedifferentiation.
Malignant transformation of a benign lipoma to malignant liposarcoma is practically unknown.8 It is crucial that the diagnosis of a well-differentiated liposarcoma
is established preoperatively, because there are differences in initial treatment, longterm management and prognosis.
(4) The incidence of liposarcoma in the hypopharynx is not well-reported in the literature, with less than 40 cases reported, almost all of which are well-differentiated liposarcoma
The value of fat-suppressed T2 or STIR sequences in distinguishing lipoma from well-differentiated liposarcoma
. Eur Radiol.
CT appearance of a well-differentiated liposarcoma
may be very similar to the remnants of infiltrated soft tissue .
Eward et al., "Can experienced observers differentiate between lipoma and well-differentiated liposarcoma
using only MRI?," Sarcoma, vol.
Caption: Figure 3: Histology of the primary site-dedifferentiated liposarcoma (a, b) and well-differentiated liposarcoma
components (c, d) and the metastasis (e, f).
It is noteworthy that imaging features of lipomas can be similar to well-differentiated liposarcomas
. Presence of imaging features such as thick enhancing septa, presence of nodular and/or globular, or nonadipose mass like areas and decreased percentage of fat within the lesion are suggestive of malignancy .
The histopathologic exam showed a well-differentiated liposarcoma
with spindle and lipoma-like cells (Grade 1), without infiltration of the testis and with free surgical margins.
Common types of liposarcoma include well-differentiated liposarcoma
, myxoid, dedifferentiated, and pleomorphic liposarcoma.
One case each of malignant fibrous histiocytoma, myxoid liposarcoma [Figure 1b], atypical lipomatous tumor/ well-differentiated liposarcoma
(ALT/WDL), and malignant mesothelioma were identified.
[sup] Liposarcomas were divided into the following five subtypes: well-differentiated liposarcoma
, dedifferentiated liposarcoma, myxoid liposarcoma, pleomorphic liposarcoma, and mixed liposarcoma.