well-differentiated liposarcoma

well-differentiated liposarcoma

A well-circumscribed, slow-growing, low-grade malignancy of fat cells, which arises de novo (i.e., not from pre-existing lipomas) in deep soft tissue of thighs, retroperitoneum, and groin of middle-aged adults. As a general rule, the deeper the tumour, the more likely it is to recur.

Epidemiology
5000 new cases/year (US), which is 20% of all soft-tissue tumours; average age 50, slightly more common in males.

Clinical findings
Mass, history of trauma, swelling, reduced range of motion, increased varicose veins, fatigue, abdominal pain, nausea, vomiting, weight loss, compartment syndrome.
References in periodicals archive ?
Atypical lipomatous tumor is preferred by WHO Classification of Tumours of Soft Tissue and Bone (1) (2013 edition) over the term well-differentiated liposarcoma if the tumor occurs in the extremities because this is a locally aggressive adipocytic neoplasm with no potential for metastasis.
2],[3]&[4] Dedifferentiated liposarcoma is a tumour which has a highly cellular non-lipogenic component along with a well-differentiated liposarcoma.
The histopathologic exam showed a well-differentiated liposarcoma with spindle and lipoma-like cells (Grade 1), without infiltration of the testis and with free surgical margins.
Common types of liposarcoma include well-differentiated liposarcoma, myxoid, dedifferentiated, and pleomorphic liposarcoma.
Imaging of fatty tumors: Distinction of lipoma and well-differentiated liposarcoma.
One case each of malignant fibrous histiocytoma, myxoid liposarcoma [Figure 1b], atypical lipomatous tumor/ well-differentiated liposarcoma (ALT/WDL), and malignant mesothelioma were identified.
sup][4] Liposarcomas were divided into the following five subtypes: well-differentiated liposarcoma, dedifferentiated liposarcoma, myxoid liposarcoma, pleomorphic liposarcoma, and mixed liposarcoma.
Histopathology confirmed a well-differentiated liposarcoma with rare mitoses.
Retroperitoneal well-differentiated liposarcoma presenting as an incarcerated inguinal hernia.
Infiltrative lipomas, previously referred to as lipomatosis or well-differentiated liposarcoma, are locally aggressive tumors that infiltrate surrounding fibrous tissue, muscle, fascia, articular capsules, blood vessels, nerves, and bone.
27) Karyotypic analysis has shown that well-differentiated liposarcoma is characterized by the presence of ring or giant marker chromosomes.
In the literature we reviewed Well-Differentiated Liposarcoma (WDL) and found Myxoid Liposarcoma (ML) to be the most commonly encountered type, accounting for 48.