well-differentiated liposarcoma


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well-differentiated liposarcoma

A well-circumscribed, slow-growing, low-grade malignancy of fat cells, which arises de novo (i.e., not from pre-existing lipomas) in deep soft tissue of thighs, retroperitoneum, and groin of middle-aged adults. As a general rule, the deeper the tumour, the more likely it is to recur.

Epidemiology
5000 new cases/year (US), which is 20% of all soft-tissue tumours; average age 50, slightly more common in males.

Clinical findings
Mass, history of trauma, swelling, reduced range of motion, increased varicose veins, fatigue, abdominal pain, nausea, vomiting, weight loss, compartment syndrome.
References in periodicals archive ?
Well-differentiated liposarcoma of the retroperitoneum: a clinicopathologic analysis of 20 cases, with particular attention to the extent of low-grade dedifferentiation.
Malignant transformation of a benign lipoma to malignant liposarcoma is practically unknown.8 It is crucial that the diagnosis of a well-differentiated liposarcoma is established preoperatively, because there are differences in initial treatment, longterm management and prognosis.
(4) The incidence of liposarcoma in the hypopharynx is not well-reported in the literature, with less than 40 cases reported, almost all of which are well-differentiated liposarcoma. (5,6)
The value of fat-suppressed T2 or STIR sequences in distinguishing lipoma from well-differentiated liposarcoma. Eur Radiol.
CT appearance of a well-differentiated liposarcoma may be very similar to the remnants of infiltrated soft tissue [10].
Eward et al., "Can experienced observers differentiate between lipoma and well-differentiated liposarcoma using only MRI?," Sarcoma, vol.
Caption: Figure 3: Histology of the primary site-dedifferentiated liposarcoma (a, b) and well-differentiated liposarcoma components (c, d) and the metastasis (e, f).
It is noteworthy that imaging features of lipomas can be similar to well-differentiated liposarcomas. Presence of imaging features such as thick enhancing septa, presence of nodular and/or globular, or nonadipose mass like areas and decreased percentage of fat within the lesion are suggestive of malignancy [7].
The histopathologic exam showed a well-differentiated liposarcoma with spindle and lipoma-like cells (Grade 1), without infiltration of the testis and with free surgical margins.
Common types of liposarcoma include well-differentiated liposarcoma, myxoid, dedifferentiated, and pleomorphic liposarcoma.
One case each of malignant fibrous histiocytoma, myxoid liposarcoma [Figure 1b], atypical lipomatous tumor/ well-differentiated liposarcoma (ALT/WDL), and malignant mesothelioma were identified.
[sup][4] Liposarcomas were divided into the following five subtypes: well-differentiated liposarcoma, dedifferentiated liposarcoma, myxoid liposarcoma, pleomorphic liposarcoma, and mixed liposarcoma.