washout period


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washout period

A period in a clinical study during which subjects receive no treatment for the indication under study and the effects of a previous treatment are eliminated (or assumed to be eliminated).
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References in periodicals archive ?
Washout Period. Five fish per tank were sampled every 28 days, at time 9 (252 days), 10 (280 days), 11 (308 days), and 12 (336 days).
[21] found that in patients treated with monotherapy latanoprost for at least 6 months, with most greater than 1 year, experienced a significantly lower IOP of 1.3 mmHg compared to baseline measurements following a 14-day washout period. Sehi et al.
But he had taken his last dose of aspartame six days earlier, and the author-chosen washout period was only three days.
Because there was no washout period between interventions, this implied up to 8 consecutive months of reduced riboflavin intake in 84 subjects (4).
After a 2-week washout period, patients were randomized to receive treatment with diclofenac (75 mg twice daily), acetaminophen (1000 mg 4 times daily), or matching placebo for 12 weeks.
The washout period is recommended because increased creatine levels will eventually trigger the body to shut down its creatine production and transport into muscle from the blood.
Most had a big decline in saquinavir levels after the 21 days of garlic use, with good recovery after the 10-day washout period. But three volunteers did not have a significant decline in saquinavir blood levels during the 21 days of garlic use -- but did have a big drop after the washout.
In the randomized, double blind, crossover study, 28 healthy men (n=20) and women (n=8) were assigned to each of two, 4-day treatment sequences, with a washout period of 7 days between each treatment.
The researchers chose a washout period of 6 months to the development of Parkinson's disease after appendectomy, and compared the prevalence of Parkinson's disease in the general population to those with appendectomies.
Participants completed 28 days of closed-loop and SAP insulin delivery separated by a washout period; for up to six weeks postpartum, participants could continue to use the closed-loop system.