warfarin


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warfarin

 [wor´fah-rin]
a synthetic coumarinanticoagulant, usually used as the sodium salt; administered orally or intravenously. It is also used as a rodenticide, causing fatal hemorrhaging in any mammal that consumes a sufficient dose, including humans.

war·fa·rin

(wōr'fă-rin),
An anticoagulant with the same actions as dicumarol; also used as a rodenticide; also available as the potassium salt, with the same actions and uses.

warfarin

/war·fa·rin/ (wor´fah-rin) a synthetic coumarinanticoagulant administered as the sodium salt; it is also used as a rodenticide, causing fatal hemorrhaging in any mammal consuming a sufficient dose.

warfarin

(wôr′fər-ĭn)
n.
A white crystalline compound, C19H16O4, that inhibits production of prothrombin and is used in the form of its sodium salt as an anticoagulant drug and as a rodenticide.

warfarin

An anticoagulant that inhibits synthesis of liver-dependent coagulation factors (the prothrombin complex, factors II, VII, IX and X), which are formed by gamma-carboxylation of precursor proteins.
 
Indications
Prevention of uncomplicated distal DVT, prophylaxis and prevention of thromboembolism, post-acute myocardial infarction.

Monitoring
Warfarin therapy is monitored by serial evaluation of PT–2-3-fold > normal 12–16 seconds; its activity is increased by phenylbutazone, clofibrate (by outcompeting with warfarin for plasma-protein binding sites and decreased by barbiturates, which stimulate hepatic metabolism).

warfarin

Coumadin Hematology An anticoagulant that inhibits synthesis of liver-dependent coagulation factors–the prothrombin complex, factors II, VII, IX and X, which are formed by γ-carboxylation of precursor proteins Indications Prevention of uncomplicated distal DVT, prophylaxis and prevention of thromboembolism, post-acute MI; warfarin therapy is monitored by serial evaluation of PT–2-3-fold > normal 12–16 secs; its activity is ↑ by phenylbutazone, clofibrate–by outcompeting with warfarin for plasma protein binding sites and ↓ by barbiturates, which stimulate hepatic metabolism. See Superwarfarin. Cf Heparin.

war·fa·rin

(wōr'fă-rin)
An anticoagulant and rodenticide.

warfarin

An ANTICOAGULANT drug used to prevent blood from clotting in the blood vessels. The drug is on the WHO official list. A brand name is Marevan.

Warfarin

A drug given to control the formation of blood clots. The PT test can be used to monitor patients being treated with warfarin.

Warfarin,

Wisconsin Alumni Research Foundation (WARF).
Warfarin - oral anticoagulant, named for the foundation.

war·fa·rin

(wōr'fă-rin)
Anticoagulant with same actions as dicumarol.

warfarin

a coumarin compound used as an anticoagulant in humans and as a rodenticide, with serious toxicity implications for all species. It is readily absorbed from the intestinal tract and acts to inhibit the reduction of oxidized vitamin K, resulting in a depletion of active vitamin K that is required for carboxylation of coagulation factors VII, IX, X and II.
Accidental poisoning in all species causes massive, spontaneous hemorrhage and death due to anemia. Less severe cases often show pulmonary hemorrhage. In pigs it is the legs that are affected preferentially and in dogs hemorrhage into the anterior mediastinum and lungs is common. Vitamin K is the specific antidote.

Patient discussion about warfarin

Q. how medications effect me side effects warfarin,s effect what does I and R mean i have my I and R each week, what is it,s function..........

A. It depends what the heart condition is but probably not. Not being on warfarin may increase your risk of stroke. Most importantly you need to address this wuestion with the doctor that prescribe the warfarin to you.

More discussions about warfarin
References in periodicals archive ?
Consistent Diet Important With Warfarin Warfarin blocks the action of vitamin K, which the liver needs to make clotting factors.
One DOAC is better than warfarin at one thing; 2 others are better at another
Warfarin despite being a very effective drug has wide inter individual variability in dose requirements to attain efficient anticoagulation.
Warfarin dose and the pharmacogenomics of CYP2C9 and VKORC1--rationale and perspectives.
Patients prescribed rivaroxaban had slightly lower rates of ischemic stroke or systemic embolic events than warfarin users at one year (3.
The current meta-analysis of all recent RCTs was conducted to determine whether continuation of warfarin treatment or interruption with heparin bridging is more efficacious during CRD implantation.
1,2 With a high percentage of ageing population in the Khyber Pakhtunkhwa Province (KPK) and a greater proportion of this population wanting to retain their existing teeth, the number of patients taking warfarin who require dental extractions is likely to increase.
Therefore, HCPs in every practice setting need to be alert in monitoring for potential warfarin interactions with drugs and herbs and advising patients regarding herb medicines to avoid when taking warfarin.
Whereas the majority of patients in EU-PACT initiated warfarin for atrial fibrillation, more patients in COAG were being treated for venous thromboembolism.
The reported increase in antithrombin during warfarin therapy was based on assay procedures using a serum specimen.
The statement points out that other than the MI finding, the results are consistent with the results of the RELY (Randomized Evaluation of Long-Term Anticoagulation Therapy) trial, which found the MI risk was higher among those on dabigatran than those on warfarin.
CASE PRESENTATION: Warfarin Embryopathy results as a consequence of maternal warfarin intake during the antenatal period.

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