warfarin


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warfarin

 [wor´fah-rin]
a synthetic coumarinanticoagulant, usually used as the sodium salt; administered orally or intravenously. It is also used as a rodenticide, causing fatal hemorrhaging in any mammal that consumes a sufficient dose, including humans.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

war·fa·rin

(wōr'fă-rin),
An anticoagulant with the same actions as dicumarol; also used as a rodenticide; also available as the potassium salt, with the same actions and uses.
Farlex Partner Medical Dictionary © Farlex 2012

warfarin

(wôr′fər-ĭn)
n.
A white crystalline compound, C19H16O4, that inhibits production of prothrombin and is used in the form of its sodium salt as an anticoagulant drug and as a rodenticide.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

warfarin

An anticoagulant that inhibits synthesis of liver-dependent coagulation factors (the prothrombin complex, factors II, VII, IX and X), which are formed by gamma-carboxylation of precursor proteins.
 
Indications
Prevention of uncomplicated distal DVT, prophylaxis and prevention of thromboembolism, post-acute myocardial infarction.

Monitoring
Warfarin therapy is monitored by serial evaluation of PT–2-3-fold > normal 12–16 seconds; its activity is increased by phenylbutazone, clofibrate (by outcompeting with warfarin for plasma-protein binding sites and decreased by barbiturates, which stimulate hepatic metabolism).
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

warfarin

Coumadin Hematology An anticoagulant that inhibits synthesis of liver-dependent coagulation factors–the prothrombin complex, factors II, VII, IX and X, which are formed by γ-carboxylation of precursor proteins Indications Prevention of uncomplicated distal DVT, prophylaxis and prevention of thromboembolism, post-acute MI; warfarin therapy is monitored by serial evaluation of PT–2-3-fold > normal 12–16 secs; its activity is ↑ by phenylbutazone, clofibrate–by outcompeting with warfarin for plasma protein binding sites and ↓ by barbiturates, which stimulate hepatic metabolism. See Superwarfarin. Cf Heparin.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

war·fa·rin

(wōr'fă-rin)
An anticoagulant and rodenticide.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

warfarin

An ANTICOAGULANT drug used to prevent blood from clotting in the blood vessels. The drug is on the WHO official list. A brand name is Marevan.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

Warfarin

A drug given to control the formation of blood clots. The PT test can be used to monitor patients being treated with warfarin.
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.

Warfarin,

Wisconsin Alumni Research Foundation (WARF).
Warfarin - oral anticoagulant, named for the foundation.
Medical Eponyms © Farlex 2012

war·fa·rin

(wōr'fă-rin)
Anticoagulant with same actions as dicumarol.
Medical Dictionary for the Dental Professions © Farlex 2012

Patient discussion about warfarin

Q. how medications effect me side effects warfarin,s effect what does I and R mean i have my I and R each week, what is it,s function..........

A. It depends what the heart condition is but probably not. Not being on warfarin may increase your risk of stroke. Most importantly you need to address this wuestion with the doctor that prescribe the warfarin to you.

More discussions about warfarin
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References in periodicals archive ?
By studying over 5000 individuals on warfarin initiating treatment with simvastatin it was clear that the anticuagulation subsequently was significantly increased.
Drug administration: Warfarin was administered in each rabbit through stomach tube at dose rate of 0.5 mg.kg-1.
Studies have indicated that DOACs are similar or better than warfarin in respect to safety, but Dr.
But there's a potentially larger group who could benefit from DOACs, but are given warfarin instead: patients who can't be trusted to take their medication as prescribed.
Many warfarin patients find the ability to monitor their own INR levels appealing for several reasons.
Warfarin in Anticoagulant Naive Atrial Fibrillation Patients: A Nationwide Study.
Warfarin is the most widely prescribed oral anticoagulant in the World.1,2 However, because of the narrow therapeutic index and life-threatening complications, patients must be regularly and continuously followed up.3 The warfarin dose is set according to the International Normalized Ratio (INR) level in the blood.
Looking at all patients taking warfarin (regardless of whether or not they were also taking an NSAID or antiplatelet agent), PPI co-therapy reduced the risk of hospitalization for upper GI bleeding by 24% (adjusted hazard ratio [HR]=0.76; 95% confidence interval [CI], 0.63 to 0.91), which translates into 29 fewer hospitalizations per 10,000 person-years.
In our study, in which we evaluated the effect of CYP2C9, VKORC1 genetic polymorphisms, warfarin dosages and complications, no difference was observed between the patient and control groups in terms of haplotypes in warfarin-using patients.
Despite the reported beneficial effect of vitamin K supplementation, many practitioners advise patients taking warfarin to restrict dietary vitamin K intake.
Results: The statistically significant difference was found between age groups (in years) and different levels of warfarin dose (p=0.046) along with IL-6 production.
A Danish study, undertaken by Torben Larsen , associate professor, Aalborg University Hospital, Aalborg, Denmark, and colleagues, is the first to examine the first three aforementioned OACs compared to warfarin. (Edoxaban is not yet on the market in Denmark.) Participants numbered 61,678 first-time NOAC users divided into four groups, according to medication: warfarin (35,436, 57%), dabigatran (12,701,21%) , rivaroxaban (7,192, 12%), and apixaban (6, 349, 10%).

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