waning immunity


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waning immunity

The progressive loss of protective antibodies against an antigen or disease that occurs with the passage of time. It is a crucial factor in vaccination. Booster doses of a vaccine are given when the immune response to an antigen drops below protective levels.
See also: immunity
References in periodicals archive ?
Pertussis resurgence: waning immunity and pathogen adaptation-two sides of the same coin.
23) To conclude, implementation of a MenACWY booster would enlarge the IMD protection and target the waning immunity after primary MenC immunisation.
However, the study found that pertussis outbreaks occurred in highly vaccinated populations as well, which points to waning immunity.
Development of a better pertussis vaccine has emerged as a pressing need in light of persuasive evidence of waning immunity to current vaccines.
Because of an increasing incidence of reported pertussis cases attributed to waning immunity among adults and adolescents, the Advisory Committee on Immunization Practices (ACIP) in 2005 recommended administration of a new, combined tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) for adolescents and adults aged 11-64 years (1).
Brill and Zinsser described that stress or waning immunity could reactivate R.
It's possible that in families with increased susceptibility there's an inherited genetic variation that more easily allows for waning immunity.
There was no evidence of genetic drift, although the role of waning immunity is unclear.
Waning immunity explained only some, not all, of the increased risk among vaccinated individuals, Dr.
Waning immunity with acellular pertussis led to greater vulnerability in 7- to 10-year-olds," commented Dr.
The ACIP Work Group also concluded that serologic data are consistent with waning immunity.