wallerian degeneration

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deterioration; change from a higher to a lower form, especially change of tissue to a lower or less functionally active form. When there is chemical change of the tissue itself, it is true degeneration; when the change consists in the deposit of abnormal matter in the tissues, it is infiltration. adj., adj degen´erative.
caseous degeneration caseation (def. 2).
cerebromacular degeneration (cerebroretinal degeneration)
1. degeneration of brain cells and of the macula retinae, as occurs in tay-sachs disease.
2. any lipidosis with cerebral lesions and degeneration of the retinal macula.
colloid degeneration degeneration with conversion of the tissues into a gelatinous or gumlike material.
cystic degeneration degeneration with formation of cysts.
fatty degeneration deposit of fat globules in a tissue.
fibroid degeneration degeneration of a leiomyoma with subsequent fibrosis.
hepatolenticular degeneration Wilson's disease.
hyaline degeneration a regressive change in cells in which the cytoplasm takes on a homogeneous, glassy appearance; also used loosely to describe the histologic appearance of tissues.
hydropic degeneration a form in which the epithelial cells absorb much water.
lattice degeneration of retina a frequently bilateral, usually benign asymptomatic condition, characterized by patches of fine gray or white lines that intersect at irregular intervals in the peripheral retina, usually associated with numerous, round, punched-out areas of retinal thinning or retinal holes.
macular degeneration see macular degeneration.
macular degeneration, congenital see stargardt's disease.
macular degeneration, Stargardt's stargardt's disease.
mucoid degeneration degeneration with deposit of myelin and lecithin in the cells.
mucous degeneration degeneration with accumulation of mucus in epithelial tissues.
myofibrillar degeneration damage to selective cardiac cells when surrounding interstitial cells, nerves, and capillaries remain viable.
myxomatous degeneration mucous degeneration.
spongy degeneration of central nervous system (spongy degeneration of white matter) Canavan disease.
subacute combined degeneration of spinal cord degeneration of both the posterior and lateral columns of the spinal cord, producing various motor and sensory disturbances; it is due to vitamin B12 deficiency and is usually associated with pernicious anemia. Called also Lichtheim's or Putnam-Dana syndrome.
wallerian degeneration fatty degeneration of a nerve fiber that has been severed from its nutritive source.
Zenker's degeneration Zenker's necrosis.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

wal·le·ri·an de·gen·er·a·tion

the degenerative changes the distal segment of a peripheral nerve fiber (axon and myelin) undergoes when its continuity with its cell body is interrupted by a focal lesion.
Farlex Partner Medical Dictionary © Farlex 2012

wal·le·ri·an de·gen·er·a·tion

(waw-ler'ē-ăn dĕ-jen'ĕr-ā'shŭn)
The degenerative changes observed in the distal segment of a peripheral nerve fiber (axon and myelin) when its continuity with its cell body is interrupted by a focal lesion.
Synonym(s): orthograde degeneration, secondary degeneration.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012


Augustus V., English physiologist, 1816-1870.
wallerian degeneration - degenerative changes in the distal segment of a peripheral nerve fiber when its continuity with its cell body is interrupted by a focal lesion. Synonym(s): orthograde degeneration; secondary degeneration
Medical Eponyms © Farlex 2012
References in periodicals archive ?
The role of [H.sub.2]S in the Schwann cell response to peripheral nerve injury has been well established by experimental evidence, and the importance of [H.sub.2]S signaling during Wallerian degeneration, where it broadly affects Schwann cell dedifferentiation and proliferation, has been repeatedly demonstrated.
Jang et al., "Transient lysosomal activation is essential for p75 nerve growth factor receptor expression in myelinated Schwann cells during Wallerian degeneration," Anatomy & Cell Biology, vol.
Values for the Wallerian degeneration, number of myelinated axons, degree of muscle atrophy and MDA level were analyzed using one-way ANOVA followed by Duncan's test for multiple comparisons.
Distally, Wallerian degeneration takes place, resulting in axonal degeneration.
Expression of the neu proto-oncogene by Schwann cells during peripheral nerve development and Wallerian degeneration. J Neurosci Res 1992; 31: 622-634.
Diffusion tensor imaging detects Wallerian degeneration of the corticospinal tract early after cerebral infarction.
Rotshenker, "The cytokine network of Wallerian degeneration: tumor necrosis factor-alpha, interleukin-1alpha, and interleukin-1beta," The Journal of Neuroscience, vol.
Wallerian degeneration occurred in the dorsal funiculus where the white discoloration was observed on gross examination.
Within 2 to 3 days of injury, edema forms in the axonal stumps and they undergo Wallerian degeneration. The hallmarks of Wallerian degeneration are axoplasmic condensation and myelin and axonal disintegration.
Nerve conduction is interrupted and the nerve fiber undergoes retrograde degeneration (Wallerian degeneration).
NCCT of Brain revealed hemi-atrophy of left cerebral hemisphere, leading to dilatation of sulci and cisterns as well as ex-vacuo dilatation of left lateral ventricle, atrophy of left cortico-spinal tract/cerebral peduncle in left half of mid-brain suggestive of wallerian degeneration. Due to volume loss, there is compensatory thickening of left frontal, parietal and squamous part of left temporal bone with enlargement of left frontal sinus and ethmoid sinus.
Vascular occlusions in the perinatal period in the middle cerebral vascular territory, unilateral cerebral arterial circulation anomalies, coarctation of the middle aortic arch, mesencephalon hypoplasia and Wallerian degeneration are proposed as some of the causes for the Congenital variety [5].