vulvar intraepithelial neoplasia


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Related to vulvar intraepithelial neoplasia: Vulvar cancer, Lichen sclerosus, Vulvar vestibulitis

vulvar intraepithelial neoplasia

preinvasive squamous cell carcinoma (carcinoma in situ) limited to vulvar epithelium; like vaginal or cervical intraepithelial neoplasia, graded histologically on a scale from 1 to 3 or subdivided into low-grade and high-grade intraepithelial malignancy; usually related to human papilloma virus infection; may progress to invasive carcinoma.

vulvar intraepithelial neoplasia

Gynecology An umbrella term for a precancerous state characterized by the presence of dysplastic cells within the vulvar epithelium, which ranges from low-grade to carcinoma in situ. See Carcinoma in situ, CIN, Intraepithelial neoplasia.

vul·var in·tra·ep·i·the·li·al ne·o·pla·si·a

(vŭl'văr in'tră-ep'i-thē'lē-ăl nē'ō-plā'zē-ă)
Preinvasive squamous cell carcinoma (carcinoma in situ) limited to vulvar epithelium; like vaginal or cervical intraepithelial neoplasia, graded histologically on a scale from 1-3 or subdivided into low-grade and high-grade intraepithelial malignancy; usually related to human papillomavirus infection; may progress to invasive carcinoma.

vulvar intraepithelial neoplasia

Abbreviation: VIN
Precancerous, noninvasive lesions of the squamous epithelium of the vulva.

Symptoms

Symptoms are vulvar pain, itching, or burning. Risk factors include exposure to Human Papilloma Virus 16 and 18, type 2 Herpes Simplex Virus, and smoking.

Diagnosis

Diagnosis is made by biopsy of the lesion.

Treatment

Treatments include brief observation to see if the condition spontaneously remits, topically applied chemotherapy, laser ablation, or wide surgical excision.

Synonym: vaginal intraepithelial neoplasia
See also: neoplasia
References in periodicals archive ?
0/1 + 2+ 3+ NE 25 0 0 LS 7 3 0 HG-VIN 9 7 0 d-VIN 1 9 8 ISCC 6 11 15 Grade 1 3 5 3 Grade 2 2 4 6 Grade 3 1 2 6 Abbreviations: d-VIN, differentiated vulvar intraepithelial neoplasia; HG-VIN, high-grade vulvar intraepithelial neoplasia, classic type; ISCC, invasive squamous cell carcinoma of the vulva; LS, lichen sclerosus; NE, normal vulvar squamous epithelia.
The agent has previously been reported as efficacious against vulvar intraepithelial neoplasia (VIN), but "only in small, uncontrolled studies.
GARDASIL is not intended to be used for treatment of active external genital lesions; cervical, vulvar, vaginal, and anal cancers; cervical intraepithelial neoplasia, vulvar intraepithelial neoplasia, vaginal intraepithelial neoplasia, or anal intraepithelial neoplasia.
Be skeptical of biopsy results suggesting vulvar intraepithelial neoplasia III if the patient was recently treated with podophyllin for condylomata, Dr.
Imiquimod, an immune response modifier, holds promise for being an effective treatment for select cases of vulvar intraepithelial neoplasia III, said Dr.
GARDASIL is not intended to be used for treatment of active external genital lesions; cervical, vulvar, and vaginal cancers; cervical intraepithelial neoplasia, vulvar intraepithelial neoplasia, or vaginal intraepithelial neoplasia.
Furthermore, there are examples of cancer vaccine candidates targeting the E6 and/or E7 proteins achieving significant clinical efficacy in patients with cervical or vulvar intraepithelial neoplasia, yet the CTL responses achieved in such studies were lower than those observed in the current VGX-3100 study.