vulvar intraepithelial neoplasia


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Related to vulvar intraepithelial neoplasia: Vulvar cancer, Lichen sclerosus, Vulvar vestibulitis

vulvar intraepithelial neoplasia

preinvasive squamous cell carcinoma (carcinoma in situ) limited to vulvar epithelium; like vaginal or cervical intraepithelial neoplasia, graded histologically on a scale from 1 to 3 or subdivided into low-grade and high-grade intraepithelial malignancy; usually related to human papilloma virus infection; may progress to invasive carcinoma.
Farlex Partner Medical Dictionary © Farlex 2012

vulvar intraepithelial neoplasia

Gynecology An umbrella term for a precancerous state characterized by the presence of dysplastic cells within the vulvar epithelium, which ranges from low-grade to carcinoma in situ. See Carcinoma in situ, CIN, Intraepithelial neoplasia.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

vul·var in·tra·ep·i·the·li·al ne·o·pla·si·a

(vŭl'văr in'tră-ep'i-thē'lē-ăl nē'ō-plā'zē-ă)
Preinvasive squamous cell carcinoma (carcinoma in situ) limited to vulvar epithelium; like vaginal or cervical intraepithelial neoplasia, graded histologically on a scale from 1-3 or subdivided into low-grade and high-grade intraepithelial malignancy; usually related to human papillomavirus infection; may progress to invasive carcinoma.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

vulvar intraepithelial neoplasia

Abbreviation: VIN
Precancerous, noninvasive lesions of the squamous epithelium of the vulva.

Symptoms

Symptoms are vulvar pain, itching, or burning. Risk factors include exposure to Human Papilloma Virus 16 and 18, type 2 Herpes Simplex Virus, and smoking.

Diagnosis

Diagnosis is made by biopsy of the lesion.

Treatment

Treatments include brief observation to see if the condition spontaneously remits, topically applied chemotherapy, laser ablation, or wide surgical excision.

Synonym: vaginal intraepithelial neoplasia
See also: neoplasia
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Is the assumed natural history of vulvar intraepithelial neoplasia III based on enough evidence: a systematic review of 3322 published patients.
Differentiated vulvar intraepithelial neoplasia is often found in lesions, previously diagnosed as lichen sclerosus, which have progressed to vulvar squamous cell carcinoma.
The patients had multifocal, human papilloma virus-associated vulvar intraepithelial neoplasia III (VIN III) that had been treated unsuccessfully with excision, laser surgery and other methods.
Immunohistochemical localization of telomerase hTERT protein and analysis of clonality in multifocal vulvar intraepithelial neoplasia. Am J Clin Pathol.
624.01 Vulvar intraepithelial neoplasia I [vim I] Mild dysplasia of vulva 624.02 Vulvar intraepithelial neoplasia II [VIN II] Moderate dysplasia of vulva 624.09 Other dystrophy of vulva Kraurosis of vulva Leukoplakia of vulva 233.30 Unspecified female genital organ 233.31 Vagina Severe dysplasia of vagina Vaginal intraepithelial neoplasia III [VAIN III] 233.32 Vulva Severe dysplasia of vulva Vulvar intraepithelial neoplasia III [VIN III] 233.39 Other female genital organ Until now, you have had only three codes to work with: 623.0 [dysplasia of vagina]; 624.0 [dystrophy of vulva]; and 233.3 [Ca in situ of other and unspecified genital organs].
Vulvar intraepithelial neoplasia (VIN) and vaginal intraepithelial neoplasia (VAIN) are not uncommon in women with HIV infection, and they often develop concurrently with high-grade cervical lesions.
Younger women are most likely to have the poorly differentiated warty or basilar type of vulvar intraepithelial neoplasia (VIN) III in which associated HPV DNA is frequently found, said Dr.
Biopsies taken from an area within weeks or months of topical podophyllin treatment will have mitotic figures that can mislead pathologists to report vulvar intraepithelial neoplasia (VIN) III, he said at an ob.gyn.