vorozole


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vorozole

Endocrinology An aromatase inhibiting antiestrogen used as 2nd-line therapy for advanced breast CA in postmenopausal ♀ with disease progression after tamoxifen therapy. See Antiestrogen therapy, Tamoxifen.
References in periodicals archive ?
The effective nonsteroidal aromatase inhibitors, Letrozole, Vorozole, and Anastrozole, having triazole moieties, are useful for preventing breast cancer [22].
2-Nitrobenzohydrazide as a Potent Urease Inhibitor: Synthesis, Characterization and Single Crystal X-ray Diffraction Analysis
Effects of oral administration of tamoxifen, toremifene, dehydroepiandrosterone, and vorozole on u t e r i n e histomorphology in the rat.
Histological changes induced by tamoxifen versus tamoxifen plus 13-cis-retinoic acid on rabbit uterine glands
Thomas et al., "Aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole and vorozole templates," ChemMedChem, vol.
The sulfatase pathway for estrogen formation: targets for the treatment and diagnosis of hormone-associated tumors
Also several compounds containing 1,2,4-triazole rings are well known as drugs; for example, fluconazole is used as an antimicrobial drug, while vorozole, letrozole, and anastrozole are nonsteroidal drugs used for the treatment of cancer.
Environ-economic synthesis and characterization of some new 1,2,4-triazole derivatives as organic fluorescent materials and potent fungicidal agents
Thus, several potent drugs possessing triazole nucleus have been applied in medicine, like, Alprazolam (anxiolytic agent and tranquilizer), Anastrozole, Letrozole, Vorozole (antineoplastics and nonsteroidal competitive aromatase inhibitors), Estazolam (hypnotic, sedative and tranquilizer), Etoperidone (antidepressant), Fluconazole, Itraconazole, Terconazole (antifungal agents), Ribavirin (antiviral agent), Benatradin (diuretic), Rilmazafon (hypnotic, anxiolytic and used in the case of neurotic insomnia), Nefazodone (antidepressant and 5-HT2 A-antagonist), Rizatriptan (antimigraine agent), Trapidil (hypotensive), Trazodone (antidepressant, anxiolytic and selectively inhibits central serotonin uptake) and Triazolam (sedative and hypnotic) [18].
Efficient synthesis of a novel class of 1, [omega]-bis(triazoles) and 1, [omega]-bis[[l,2,4]triazolo[3,4-b][l,3,4]thiadiazoles] with potential antimicrobial activity
This local production can substantially support the growth of estrogen-responsive tumors, and treatment with azole compounds (letrozole, anastrozole, vorozole, or fadrozole) suppresses estrogen production dramatically in these patients.
Inhibition of breast cancer tissue aromatase activity and estrogen concentrations by the third-generation aromatase inhibitor vorozole. Cancer Res 57:2109-2111.
Azole fungicides affect mammalian steroidogenesis by inhibiting sterol 14[alpha]-demethylase and aromatase. (Research)
More specific targeting of estrogen synthesis was necessary, leading to the creation of the selective aromatase inhibitors anastrozole (Arimidex[R]), letrozole (Femara[R]), and vorozole (Rizivor[R]).
Drug discoveries on the road to preventing breast cancer
In addition to these, there are a number of 1,2,4-triazole-containing drugs on the market like letrozole, vorozole and anastrozole (antitumor) [20], ribavirin, viramidine (antiviral) [21], rizatriptan (antimigrane) [22], fluconazole, itraconazole, terconazole (antifungal) [23], loreclezole (sedative and anticonvulsant) [24], hexaconazole, myclobutanil, triadimefon and tebuconazole (fungicide) [25].
Synthesis and Biological Significances of New Heterocyclic Compounds Containing 5-(4-Chlorobenzyl)-3-(4-Chlorophenyl)-1H-1,2,4-triazol Ring
In medicine, several potent drugs possessing triazole nucleus have been applied, like, Alprazolam (anxiolytic agent and tranquilizer), Anastrozole, Letrozole, Vorozole (antineoplastics and nonsteroidal competitive aromatase inhibitors), Estazolam (hypnotic, sedative and tranquilizer), Etoperidone (antidepressant), Fluconazole, Itraconazole, Terconazole (antifungal agents), Ribavirin (antiviral agent), Benatradin (diuretic), Rilmazafon (hypnotic, anxiolytic and used in the case of neurotic insomnia), Nefazodone (antidepressant and 5-HT2 A-antagonist), Rizatriptan (antimigraine agent), Trapidil (hypotensive), Trazodone (antidepressant, anxiolytic and selectively inhibits central serotonin uptake) and Triazolam (sedative and hypnotic) [23].
Synthesis of novel 1,[omega]-bis[4-[(arylcarbamothioylamino)carbamoyl]-phenoxy]-alkanes and 1,[omega]-bis[4-(4-aryl-5-thioxo-1h-1,2,4-triazol-3-yl)phenoxy]alkanes with potential antimicrobial activity
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