vorozole


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vorozole

Endocrinology An aromatase inhibiting antiestrogen used as 2nd-line therapy for advanced breast CA in postmenopausal ♀ with disease progression after tamoxifen therapy. See Antiestrogen therapy, Tamoxifen.
References in periodicals archive ?
The effective nonsteroidal aromatase inhibitors, Letrozole, Vorozole, and Anastrozole, having triazole moieties, are useful for preventing breast cancer [22].
Effects of oral administration of tamoxifen, toremifene, dehydroepiandrosterone, and vorozole on u t e r i n e histomorphology in the rat.
Thomas et al., "Aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole and vorozole templates," ChemMedChem, vol.
Also several compounds containing 1,2,4-triazole rings are well known as drugs; for example, fluconazole is used as an antimicrobial drug, while vorozole, letrozole, and anastrozole are nonsteroidal drugs used for the treatment of cancer.
Thus, several potent drugs possessing triazole nucleus have been applied in medicine, like, Alprazolam (anxiolytic agent and tranquilizer), Anastrozole, Letrozole, Vorozole (antineoplastics and nonsteroidal competitive aromatase inhibitors), Estazolam (hypnotic, sedative and tranquilizer), Etoperidone (antidepressant), Fluconazole, Itraconazole, Terconazole (antifungal agents), Ribavirin (antiviral agent), Benatradin (diuretic), Rilmazafon (hypnotic, anxiolytic and used in the case of neurotic insomnia), Nefazodone (antidepressant and 5-HT2 A-antagonist), Rizatriptan (antimigraine agent), Trapidil (hypotensive), Trazodone (antidepressant, anxiolytic and selectively inhibits central serotonin uptake) and Triazolam (sedative and hypnotic) [18].
This local production can substantially support the growth of estrogen-responsive tumors, and treatment with azole compounds (letrozole, anastrozole, vorozole, or fadrozole) suppresses estrogen production dramatically in these patients.
Inhibition of breast cancer tissue aromatase activity and estrogen concentrations by the third-generation aromatase inhibitor vorozole. Cancer Res 57:2109-2111.
More specific targeting of estrogen synthesis was necessary, leading to the creation of the selective aromatase inhibitors anastrozole (Arimidex[R]), letrozole (Femara[R]), and vorozole (Rizivor[R]).
In addition to these, there are a number of 1,2,4-triazole-containing drugs on the market like letrozole, vorozole and anastrozole (antitumor) [20], ribavirin, viramidine (antiviral) [21], rizatriptan (antimigrane) [22], fluconazole, itraconazole, terconazole (antifungal) [23], loreclezole (sedative and anticonvulsant) [24], hexaconazole, myclobutanil, triadimefon and tebuconazole (fungicide) [25].
In medicine, several potent drugs possessing triazole nucleus have been applied, like, Alprazolam (anxiolytic agent and tranquilizer), Anastrozole, Letrozole, Vorozole (antineoplastics and nonsteroidal competitive aromatase inhibitors), Estazolam (hypnotic, sedative and tranquilizer), Etoperidone (antidepressant), Fluconazole, Itraconazole, Terconazole (antifungal agents), Ribavirin (antiviral agent), Benatradin (diuretic), Rilmazafon (hypnotic, anxiolytic and used in the case of neurotic insomnia), Nefazodone (antidepressant and 5-HT2 A-antagonist), Rizatriptan (antimigraine agent), Trapidil (hypotensive), Trazodone (antidepressant, anxiolytic and selectively inhibits central serotonin uptake) and Triazolam (sedative and hypnotic) [23].