von Willebrand factor


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fac·tor VIII

in the clotting of blood, also known as: antihemophilic factor A (Brinkhous), antihemophilic globulin (1) (Patek and Taylor), antihemophilic globulin A (Cramer), plasma thromboplastin factor (Ratnoff), plasma thromboplastin factor A (Aggeler), thromboplastic plasma component (Shinowara), thromboplastinogen (Quick), prothrombokinase (Feissly), platelet cofactor (Johnson), plasmokinin (Laki), thrombokatilysin (Leggenhager), and proserum prothrombin conversion accelerator. Factor VIII participates in the clotting of the blood by forming a complex with factor IXa, platelets, and calcium and by enzymatically catalyzing the activation of factor X. Deficiency of factor VIII is associated with classic hemophilia A. Factor VIIIC is the coagulant component of factor VIII which, in normal people, circulates in the plasma complexed with Factor VIIIR (von Willebrand factor), the plasma factor VIII-related protein, a large glycoprotein component that is synthesized by endothelial cells and megakaryocytes, and circulates in the plasma where it binds to arteries that have lost their endothelial cell linings, creating a surface to which platelets adhere. Disorders involving factor VIIIR comprise a heterogenous group of abnormalities called von Willebrand disease. A deficiency of factor VIII can lead to impaired blood coagulation.

von Willebrand factor

Hematology A large–> 20,000 kD multimeric molecule composed of ± 200 kD monomers, synthesized by vascular endothelium, megakaryocytes and platelets; vWF's hemostatic efficiency is related to multimer size. See Rocket electrophoresis.

von Willebrand factor

A plasma protein secreted by endothelial cells that helps platelets to adhere to the damaged lining of blood vessels.

von Willebrand factor (vWF)

A protein found in the blood that is involved in the process of blood clotting.
References in periodicals archive ?
Kroll, "Shear stress-induced von willebrand factor binding to platelet glycoprotein Ib initiates calcium influx associated with aggregation," Blood, vol.
Denis, "von Willebrand factor: the old, the new and the unknown," Journal of Thrombosis and Haemostasis, vol.
Petit et al., "Clinical and prognostic implications of low or high level of von Willebrand factor in patients with Waldenstrom macroglobulinemia," Blood, vol.
Ruggeri, "Developing basic and clinical research on von Willebrand factor and von Willebrand disease," Thrombosis and Haemostasis, vol.
Von Willebrand factor ristocetin cofactor (VWF: RCo) activity was measured with an in-house assay in a aggregometer (Chronolog Aggregometer 490) that measures the rate of aggregation of platelets in the presence of VWF and ristocetin.
[8] This modality of treatment depletes the circulating antibodies against ADAMTS13 and the very high molecular weight von Willebrand factor multimers.
Men and women are equally affected by VWD, which is caused by a deficiency or defect in von Willebrand factor, a critical protein for blood clotting.
Colhoun, "Von Willebrand factor in type 1 diabetes: its relationship with endothelial nitric oxide production and coronary artery calcification," Medical Science Monitor, vol.
von Willebrand factor (VWF), a multimeric glycoprotein produced by endothelial cells and megakaryocytes, plays important roles in platelet adhesion at the sites of vascular injury and in the coagulation process through stabilization of factor VIII [1-3].
Von Willebrand disease (vWD) is the most common inherited bleeding disorder in humans, occurring in about 1% of women and caused by a deficiency or abnormality in the von Willebrand factor (vWF) (1).