von Willebrand's disease


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.
Related to von Willebrand's disease: hemophilia, Von Willebrand factor, DDAVP

von Willebrand's disease

 [von vil´ĕ-brahnts]
a congenital bleeding disorder, inherited as an autosomal dominant trait, characterized by a prolonged bleeding time, deficiency of von Willebrand's factor, and often impairment of platelet adhesion. It is associated with epistaxis and increased bleeding after trauma or surgery, menorrhagia, and postpartum bleeding. Called also angiohemophilia and pseudohemophilia.

von Willebrand's disease

A rare group of hereditary bleeding disorders, similar to HAEMOPHILIA but usually less sevee, due to deficiency of a clotting factor necessary for PLATELET adhesion to blood vessel walls and as a carrier for Factor VIII. The condition is usually inherited as an autosomal dominant and, unlike haemophilia, occurs equally in both sexes. Some cases are automal recessive. The mutations, which are many, are on the short arm of chromosome 12. The von Willebrand factor (vWF) is a protein, the levels of which are raised in pregnancy. (E. A. von Willebrand, 1870–1949, Swedish physician).

von Willebrand's disease

An inherited lifelong bleeding disorder caused by an abnormal gene, similar to hemophilia. The gene defect results in a decreased blood concentration of a substance called von Willebrand's factor (vWF).
References in periodicals archive ?
The rapid differentiation of type IIb von Willebrand's disease from platelet-type (pseudo) von Willebrand's disease by the "neutral" monoclonal antibody binding assay.
Serial studies in von Willebrand's disease: variability versus "variants".
(9,15,24) Von Willebrand's disease is acknowledged to be the most common hereditary bleeding disorder.
A Von Willebrand's disease (vWD) is the most common congenital bleeding disorder.
This patient was placed on a regimen of oral contraceptives, which are often very effective in patients with von Willebrand's disease. To further reduce her menstrual flow, intranasal desmopressin was added to her treatment during her third menses.
Be aware of any preexisting abnormalities of coagulation, such as hemophilia, von Willebrand's disease, and factors associated with liver disease.
She suffers from a form of Von Willebrand's disease and needs several injections a week to help her blood clot.
Von Willebrand's disease is the most common hematologic disorder in women, occurring in about 1% of the population, and the initial presenting symptom may be abnormal menstrual bleeding or hemorrhage at menstruation.
Treatment of blood with anti-vWf or ATA causes a decrease in vWf function, simulating von Willebrand's disease (vWd).
She suffers from a severe form of Von Willebrand's disease.