vitronectin


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vitronectin

 [vit″ro-nek´tin]
a multifunctional adhesive glycoprotein found in serum and various tissues. Its functions include regulation of the coagulation, fibrinolytic, and complement cascades, and it plays a role in hemostasis, wound healing, tissue remodeling, and cancer. It mediates the inflammatory and repair reactions at sites of tissue injury and promotes adhesion, spreading, and migration of cells. It has been shown to be identical to S protein, which was identified as an inhibitor of complement activation, binding the membrane attack complex and preventing its insertion into the membrane.

vit·ro·nec·tin

(vit'rō-nek'tin), [MIM*193190]
A plasma glycoprotein involved in inflammatory and repair reactions at sites of tissue damage.

vit·ro·nec·tin

(vit'rō-nek'tin)
A plasma glycoprotein involved in inflammatory and repair reactions at sites of tissue damage.
References in periodicals archive ?
AAC50945 XM_001623719.1 1e-09 Proteoglycan Dystroglycan AAH12740 XM_001621519.1 8e-25 Fibromodulin CAA51418 XM_001629115 2e-15 Fibronectin 1 NM_212476 XM_001635202.1 1e-26 Hemicentin NP_114141.2 XM_001625345.1 4e-116 Matrilin 1 NP_002370 XM_001618434 1e-42 Matrilin 2 AAH10444 XM_001636411 2e-91 Netrin 1 NP_004813 XM_001628849 3e-158 Netrin G1 NP_055732 XM_001628514 1e-145 Osteomodulin NP_005005 XM_001638987 4e-10 Osteonectin AAA60993 XM_001626392 1e-09 Podocan AAP79898 XM_001631425 6e-16 Reelin AAC51105 XM_001635471 2e-04 Syndecan 1 EAX00831 XM_001629466 0.24 Syndecan 2 NM_002998 XM_001637329 1.8 Syndecan 3 NP_055469 XM_001629466 1.9 Syndecan 4 NM_002999 XM_001641418 0.12 Tenascin CAA39628 XM_001638256 6e-64 Vitronectin EAW51082 XM_001633180 1e-13 von Willebrand fac.
An increased surface charge density at highly curved surfaces and sharp edges can explain the mechanism of adhesion between the negatively charged titanium surface and a negatively charged osteoblast, mediated by charged proteins with a distinctive quadrupolar internal charge distribution, fibronectin, and vitronectin [142, 143].
Microglial expression of alphavbeta3 and alphavbeta5 integrins is regulated by cytokines and the extracellular matrix: beta5 integrin null microglia show no defects in adhesion or MMP-9 expression on vitronectin. Glia 2009; 57: 714-723, doi: 10.1002/glia.20799.
Being [PrP.sup.C] a GPI-anchored protein, it mainly localizes in lipid rafts of cellular membranes where it can interact in trans with a variety of signaling molecules, including caveolin-1, Fyn, and Src tyrosine kinases [58], or with other cell-surface proteins as NCAM [59], stress-inducible protein 1 [60-62], vitronectin, lipoprotein receptor-related protein 1 [63, 64], or reelin [65].
Jang, "The effect of the surface modification of titanium using a recombinant fragment of fibronectin and vitronectin on cell behavior," Biomaterials, vol.
Phase two consists in molecular specific reactions between bacterial surface structures and substratum surfaces, uncoated or coated with host matrix proteins (i.e., albumin, fibronectin, fibrinogen, vitronectin, and laminin).
Insulin like growth factor-II bound to vitronectin enhances MCF-7 breast cancer cell migration.
Toward that end we launched an episomal reprogramming kit, including Episomal iPSC Reprogramming Vectors, Vitronectin, and Essential 8 Medium, that we began distributing through Life Technologies in 2012.
ITGB5 belongs to the heterodimeric integrin protein family, and [[alpha].sub.v][[beta].sub.5] integrin functions as a receptor for fibronectin [55] and vitronectin [56].
In our preliminary experiment, imogolite showed high adsorption ability with cell-adhesive proteins such as fibronectin or vitronectin. The cell-adhesive proteins might be more easily adsorbed on the fiber surfaces of INT-modified cotton-like PLLA/SiV than those of the PLLA/SiV.
CD41/CD61 antigen forms the GPIIb/IIIa complex which acts as a receptor for fibrinogen, von Willebrand factor (vWf), fibronectin and vitronectin.15