(NASDAQ: OPHT) has converted its option and entered into an exclusive global license agreement with the University of Pennsylvania for rights to develop and commercialise novel adeno-associated virus gene therapy product candidates for the treatment of Best vitelliform
macular dystrophy, also known as Best disease and other bestrophinopathies, which are diseases related to mutations to the BEST1 gene, the company said.
Patients with underlying vitelliform
dystrophy are also known to be more at risk of progression in addition to patients who already have areas of atrophy.
Ophthotech has entered into an exclusive option agreement with the University of Pennsylvania and the University of Florida Research Foundation for rights to negotiate to acquire an exclusive global license to develop and commercialize novel adeno-associated virus gene therapy product candidates for the treatment of Best vitelliform
macular dystrophy, also known as Best disease.
They look at OCT angiography in relation to the basics, artifacts, clinical systems, neovascular age-related macular degeneration, fibrotic choroidal neovascularization in age-related macular degeneration, non-neovascular age-related macular degeneration, diabetic retinopathy, arterial occlusions, retinal venous occlusions, central serious chorioretinopathy, macular telangiectasia type two, adult-onset foveomacular vitelliform
dystrophy, high myopia, uveitis, ocular oncology and radiation retinopathy, glaucoma, anterior segment vasculature, and the future.
BEST1 mutations are classically associated with Best vitelliform
macular dystrophy (BVMD), a disease restricted to the macula.
Pauleikhoff et al., "Mutations in the VMD2 gene are associated with juvenile-onset vitelliform
macular dystrophy (Best disease) and adult vitelliform
macular dystrophy but not age-related macular degeneration," European Journal of Human Genetics, vol.
Best's disease, or vitelliform
macular dystrophy, is an eye condition that usually begins to appear as a lesion in the macula during childhood (Altaweel, 2010).
Artmis RPE lipofusin birikimi --Lipofusinopatiler (Stargardt hastaligi/Best hastaligi/Pattern distrofi/Eriskin vitelliform
makula distrofisi) --Cografik atrofi sahalarinin cevresindeki bileske bolgesi (YBMD) 2.
IMPG2 is associated with autosomal dominant vitelliform
macular dystrophy 5 [MIM #616152] .