vitamin K-dependent proteins

vitamin K-dependent proteins

A group of coagulation factor proenzymes–factors II, VII, IX and X produced in the liver, which contain multiple residues of γ-carboxyglutamic acid, an amino acid produced by the post-translational action of a vitamin K-dependent γ-carboxylase on certain glutamyl residues.
References in periodicals archive ?
Vitamin K-dependent proteins in the developing and aging nervous system.
Vitamin K-dependent proteins (VKDPs), which require post-translational modification to achieve biological activity, seem to contribute to thrombus formation, vascular calcification, and vessel stiffness.
In a seminal research paper generated by the Rotterdam Study, scientists and doctors determined that increased consumption of Vitamin K2 is correlated with a reduced risk of coronary heart disease (7), building upon numerous studies describing the inhibitory effect of Vitamin K-dependent proteins on atherosclerosis.
However, scientists have since learned that you can have enough vitamin K to promote healthy blood clotting, yet still not have enough vitamin K for it to activate the Gla-proteins necessary to help prevent cardiovascular disease, osteoporosis, diabetes, and cancer, all conditions in which vitamin K-dependent proteins are known to be factors.
Other vitamin K-dependent proteins inhibited by warfarin include proteins C and S, which are involved in the fibrinolytic system.
of Wisconsin, emeritus) describes the vitamin K-dependent carboxylase, the vitamin K-eposide reductase, a closely associated enzyme, and the identification and function other vitamin K-dependent proteins.
Phylloquinone acts as a cofactor for a specific microsomal enzyme, carboxylase, which catalyzes the posttranslational carboxylation of glutamic acid (Glu) to [gamma]-carboxy glutamic acid (Gla) in vitamin K-dependent proteins (9,10).
Newly discovered vitamin K-dependent proteins, such as matrix gla protein, or MGP, are providing clues as to the mechanisms behind these associations.
Detection of vitamin K-dependent proteins in venoms with a monoclonal antibody specific for [beta]-carboxyglutamic acid.
McCann investigated the "essentiality" of known vitamin K-dependent proteins using knockout mutant mice (genetically altered mice that cannot produce the targeted protein).