vitamin K-dependent clotting factor

vitamin K-dependent clotting factor

Any of a group of coagulation factor proenzymes (factors II, VII, IX and X) produced in the liver that contain multiple residues of gamma-carboxyglutamic acid, an amino acid produced by the post-translational action of a vitamin K-dependent gamma-carboxylase on certain glutamyl residues.
 
Four other proteins have gamma-carboxyglutamic acid, and have been designated proteins C, S, Z and M; while M is poorly characterised, proteins C, S and Z have amino-terminal homology with prothrombin. Vitamin K-dependent clotting factors also have another unusual amino acid, aspartic acid.
References in periodicals archive ?
warfarin, who required urgent replacement of their Vitamin K-dependent clotting factors due to the need for an urgent surgery/invasive procedure.
The differential diagnosis includes dysfibrinogenemia, prothrombin deficiency, factor V deficiency, combined deficiency of factors V and VIII (F5F8D), factor X deficiency, and hereditary combined deficiency of the vitamin K-dependent clotting factors.
Subsequently, blood testing revealed decreased levels of vitamin K-dependent clotting factors.
These are more sensitive to a reduction in vitamin K-dependent clotting factors than are the rabbit brain thromboplastins commonly used on this continent.
Coumadin (Warfarin Sodium) limits the formation of fibrin, a primary component of nearly all clots, by inhibiting the synthesis of vitamin K-dependent clotting factors, which are formed in the liver.
About the Urgent Surgery/Invasive Procedures Clinical Trial The prospective, randomized, Phase IIIb study included 168 evaluable patients on Vitamin K antagonist therapy who required urgent replacement of their Vitamin K-dependent clotting factors prior to undergoing an urgent surgery or invasive procedure.