vitamin K epoxide reductase


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vitamin K epoxide reductase

An enzyme that is a coagulation factor. It inhibits the activation of vitamin K–dependent clotting factors in the bloodstream and alters a person's sensitivity to warfarin.
References in periodicals archive ?
Effects of demographic variables and Vitamin K epoxide reductase complex subunit 1 and cytochrome P450 2C9 polymorphisms on warfarin, weekly dosage
14) SD = Standard deviation, VKORC1 = Vitamin K epoxide reductase complex subunit 1, CYP2C9 = Cytochrome P450 2C9 Table 2: VKORC1 genotype of the patients in the study VKORC1-1639 genotype (mean [+ or -] SD) GG GA Age (years) (a) 54.
ARYx also presented a poster entitled, "The Utility of Genotyping in the First Evaluation of a Novel Vitamin K Epoxide Reductase (VKOR) Inhibitor: ATI-5923.
ATI-5923, like warfarin, is a selective inhibitor of VKOR, or vitamin K epoxide reductase enzyme, and has the same mechanism of anticoagulation action as warfarin.
Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity.
Pharmacodynamic resistance to warfarin associated with a Val66Met substitution in vitamin K epoxide reductase complex subunit 1.
A vitamin K epoxide reductase complex subunit-1 (VKORC1) mutation in a patient with vitamin K antagonist resistance.