vitamin K epoxide reductase


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vitamin K epoxide reductase

An enzyme that is a coagulation factor. It inhibits the activation of vitamin K–dependent clotting factors in the bloodstream and alters a person's sensitivity to warfarin.
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References in periodicals archive ?
Distribution of CYP2C9 and VKORC1 genotypes Frequency, Frequency, Genotype n (%) case n (%) control p VKORC1 AA 14 (35) 9 (30) AG 17 (42.5) 12 (40) GG 9 (22.5) 9 (30) 0.53 CYP2C9 *1 / *1 21 (52.5) 17 (56.7) Others 19 (47.5) 13 (53.7) 0.630 VKORC1: vitamin K epoxide reductase complex subunit 1 gene; CYP2C9: cytochrome P450 2C9; Others: CYP2C9 *1 / *2, *1 / *3, *2 / *2, *2 / *3, *3 / *3 haplotypes Table 4.
Warfarin is the specific inhibitor of vitamin K epoxide reductase (VKOR), which is coded by the VKORC1 gene.
Warfarin inhibits vitamin K epoxide reductase (VKOR), [5] an enzyme complex responsible for recycling reduced vitamin K, through interaction with subunit protein 1 (VKORC1).
Pharmacodynamic resistance to warfarin associated with a Val66Met substitution in vitamin K epoxide reductase complex subunit 1.
A vitamin K epoxide reductase complex subunit-1 (VKORC1) mutation in a patient with vitamin K antagonist resistance.
A warfarin-dosing model in Asians that uses single-nucleotide polymorphisms in vitamin K epoxide reductase complex and cytochrome P450 2C9.