vitamin D-resistant rickets


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia.
Related to vitamin D-resistant rickets: XLH, familial hypophosphatemia

vi·ta·min D-·re·sis·tant rick·ets

a group of metabolic disorders characterized by renal tubular defects in phosphate transport and bone abnormalities resulting in hypophosphatemic rickets or osteomalacia; hypocalcemia and tetany are not features. There is an autosomal dominant form [MIM*193100] and an X-linked dominant form [MIM*307800], the latter caused by mutation in the phosphate-regulating gene with homologies to endopeptidases (PHEX) on chromosome Xp. Both forms are not responsive to standard therapeutic doses of vitamin D but they may respond to very large doses of phosphate and/or vitamin D. There is also an autosomal recessive form [MIM*277440] caused by mutation in the vitamin D receptor gene (VDR) on 12q. Also sometimes called vitamin D-dependent rickets type II.

vit·a·min D-re·sis·tant rick·ets

(vīt'ă-min rĕ-zis'tănt rik'ĕts)
A group of disorders characterized by hypophosphatemic osteomalacia; heritable renal tubular disorders and abnormalities in vitamin D metabolism occur in some patients.

vi·ta·min D-re·sis·tant rick·ets

(vītă-min rĕ-zistănt rikĕts)
Metabolic disorder characterized by renal tubular defects in phosphate transport and bone abnormalities resulting in hypophosphatemic rickets or osteomalacia.
References in periodicals archive ?
Successful intermittent intravenous calcium treatment via peripheral route in a patient with hereditary vitamin D-resistant rickets and alopecia.
Prevalence of dental abscess in a population with vitamin D-resistant rickets. Pediatr Dent.
Management of the primary dentition in vitamin D-resistant rickets. Oral Surg Oral Med Oral Pathol 1982;54(2):166-71.

Full browser ?