visual cycle


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vis·u·al cy·cle

the transformation of carotenoids involved in the bleaching and regeneration of the visual pigment.
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Slowing the visual cycle reduces the availability of vitamin A derivatives (11-cis- and all-trans-retinal) to form precursors of A2E and related compounds.
Palczewski, "Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents," Annual Review of Pharmacology and Toxicology, vol.
Loss of RPE65 disrupts the visual cycle, causing accumulation of retinyl esters in lipid droplets and an increase in lipofuscin granules in the RPE cells.