visceral hypersensitivity


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visceral hypersensitivity

An abnormally low tolerance for painful stimuli in the internal organs. It is seen, e.g., in patients with irritable bowel syndrome.
References in periodicals archive ?
In preclinical oral and poster presentations, linaclotides effects on pain and its potential role in visceral organ cross-sensitization and visceral hypersensitivity were further elucidated.
Furthermore, in order to elucidate possible mechanisms of action of KT, visceral hypersensitivity was chosen as a biological marker to evaluate the rat model processed by neonatal maternal separation (NMS), a well-established early-life stress model that mimic human IBS symptoms, and then examined the content of 5-HT and NO.
Although the organic causes and mechanisms of IBS are still unclear, the early-life stress is a key predisposing factor to the functional GI disorders including visceral hypersensitivity (O'Mahony et al.
Other classes of antidepressant, such as the selective serotonin reuptake inhibitors, may also be of value as they reduce visceral hypersensitivity.
Visceral hypersensitivity is an important characteristic feature of functional gastrointestinal disorders, such as irritable bowel syndrome (IBS).
Visceral hypersensitivity is a common biological feature of irritable bowel syndrome (IBS) and other functional gastrointestinal disorders (Camilleri et al.
Allergenic reaction causes mast cells to overexcite enteric nerve endings (Guilarte 2006, Bischoff 2004) and this could explain visceral hypersensitivity, a symptom that occurs commonly in IBS-D particularly in women.
Moreover, the drug improves visceral hypersensitivity by suppressing the transmission of intestinal nociception.
In preclinical models, linaclotide reduced visceral hypersensitivity, increased fluid secretion, and accelerated intestinal transit.