Overall our 44.7% patients showed normal gastric emptying despite classical symptoms pointing some different mechanism for PDS like visceral hypersensitivity
or gastric accommodation other than delayed gastric emptying.
Altered Intestinal Microbiota Is Associated with Increased Visceral Hypersensitivity
in PI-IBS Model.
The suppression of these inflammatory mediators through regulation by MAPK signals after the PAR4-AP treatment of the BMMCs provided a molecular mechanism for the inhibition of visceral hypersensitivity
CRF has been reported to be involved in visceral hypersensitivity
, but this role of CRF has not been investigated in FD animal studies .
Kim et al., "Mucosal mast cell counts correlate with visceral hypersensitivity
in patients with diarrhea predominant irritable bowel syndrome," Journal of Gastroenterology and Hepatology, vol.
However, in people with visceral hypersensitivity
, the fermentation and increased gas production cause significant pain.
Traditionally, IBS has been considered a disorder of brain-gut-axis, and the potential underlying mechanisms of IBS associated with functional gastrointestinal disorders are multi-factorial and some hypotheses have been proposed to illustrate them, including abnormal motility, visceral hypersensitivity
, inflammation and infection, neurotransmitter imbalance, and psychosocial factors (e.g., anxiety, depression, somatisation) (Rivkin 2003; Gilkin 2005).
Iberogast normalises visceral hypersensitivity
which causes the majority of FGID symptoms.
Previous reports have described how children with recurrent abdominal pain have visceral hypersensitivity
, or decreased pain tolerance in the gut.
Yet the visceral hypersensitivity
that's central to IBS tends to render patients quite sensitive to antidepressant side effects, even at the very low doses employed.
Although the pathophysiology is elusive, it has been observed that visceral hypersensitivity
is implicated in the development of IBS symptoms and is an important hallmark feature of IBS [1, 3, 4].