virus-associated hemophagocytic syndrome

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vi·rus-·as·so·ci·at·ed he·mo·phag·o·cyt·ic syn·drome

a syndrome closely resembling malignant histiocytosis but potentially reversible, following a herpes group virus infection such as by the Epstein-Barr virus.

vi·rus-·as·so·ci·at·ed he·mo·phag·o·cyt·ic syn·drome

a syndrome closely resembling malignant histiocytosis but potentially reversible, following a herpes group virus infection such as by the Epstein-Barr virus.

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virus-associated hemophagocytic syndrome

A hemophagocytotic condition seen in immunocompromised–♂:♀ ratio, 1:1 and in non-immunocompromised–♂:♀ ratio, 4:1 subjects, often in a background of DNA virus–eg, CMV, EBV, herpesviruses, and adenovirus and rubella infections; VAHS may accompany brucellosis, candidiasis, leishmaniasis, TB, salmonellosis, GVHD, hemolytic anemia Clinical Hepatosplenomegaly, lymphadenopathy, pulmonary infiltrates, pancytopenia–with a depleted BM, skin rash DiffDx Lymphoma, malignant histiocytosis, sinus histiocytosis with massive lymphadenopathy, lymphomatoid granulomatosis.

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References in periodicals archive ?

Virus-associated hemophagocytic syndrome (VAHS) is a fulminant disorder associated with systemic viral infection and characterized pathologically by multiple-organ infiltration of hemophagocytic histiocytes into the lymphoreticular tissues.

Human herpesvirus 6-associated hemophagocytic syndrome in a healthy adult. (Dispatches)

High serum ferritin level as a marker of malignant histiocytosis and virus-associated hemophagocytic syndrome. Cancer 1987;61:2071-6.

The accelerated phase of Chediak-Higashi syndrome: an expression of the virus-associated hemophagocytic syndrome? Cancer 1984;56:524-30.