virus-associated hemophagocytic syndrome


Also found in: Acronyms.

vi·rus-·as·so·ci·at·ed he·mo·phag·o·cyt·ic syn·drome

a syndrome closely resembling malignant histiocytosis but potentially reversible, following a herpes group virus infection such as by the Epstein-Barr virus.

vi·rus-·as·so·ci·at·ed he·mo·phag·o·cyt·ic syn·drome

a syndrome closely resembling malignant histiocytosis but potentially reversible, following a herpes group virus infection such as by the Epstein-Barr virus.

virus-associated hemophagocytic syndrome

A hemophagocytotic condition seen in immunocompromised–♂:♀ ratio, 1:1 and in non-immunocompromised–♂:♀ ratio, 4:1 subjects, often in a background of DNA virus–eg, CMV, EBV, herpesviruses, and adenovirus and rubella infections; VAHS may accompany brucellosis, candidiasis, leishmaniasis, TB, salmonellosis, GVHD, hemolytic anemia Clinical Hepatosplenomegaly, lymphadenopathy, pulmonary infiltrates, pancytopenia–with a depleted BM, skin rash DiffDx Lymphoma, malignant histiocytosis, sinus histiocytosis with massive lymphadenopathy, lymphomatoid granulomatosis.
References in periodicals archive ?
High serum ferritin level as a marker of malignant histiocytosis and virus-associated hemophagocytic syndrome.
Fatal infectious mononucleosis and virus-associated hemophagocytic syndrome.
Prognosis of children with virus-associated hemophagocytic syndrome and malignant histiocytosis: correlation with levels of serum interleukin-1 and tumor necrosis factor.
Epstein-Barr virus-infected T lymphocytes in Epstein-Barr virus-associated hemophagocytic syndrome.