is classified as an immunotherapeutic agent
Previous scientific wisdom has discredited combining virotherapy
and externally added NK cell therapy to the body's natural killer (NK) cells, but there could be clear cancer-fighting benefits -- providing enough external NK cells are deployed to destroy the tumor and stop its spread, as revealed in the paper published this week in Proceedings of the National Academy of Sciences.
Subudhi et al., "Localized oncolytic virotherapy
overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy," Science Translational Medicine, vol.
The ability of oncolytic virotherapy
to induce tumor cell lysis and to stimulate an antitumor immune response in a preclinical setting has led to a number of clinical trials for different tumor types.
A phase II randomized open-label study of JX-594 in patients with advanced HCC confirmed the safety and efficacy of the oncolytic virotherapy
. This treatment was well tolerated at both high and low doses, with an intrahepatic response rate of 62% and one CR.
In contrast to single-agent pembrolizumab therapy, responders to the combination regimen included patients with very low levels of CD8+ T-cell infiltrates or negative interferon-gamma (IFN-gamma) gene signatures in baseline tumor biopsies, suggesting that oncolytic virotherapy
might make anti-programmed death-1 (PD-1) therapy more effective by altering the tumor microenvironment, the researchers concluded.
We look forward to working with Randox and to generating novel product candidates which combine the merits of oncolytic virotherapy
and local delivery of therapeutic payloads.
Evidence suggests that the host immune response seems to reduce the effectiveness of oncolytic virotherapy
. So the researchers also developed an immunocompetent melanoma mouse model.
Riga, Latvia, May 02, 2017 --(PR.com)-- Aina Muceniece Virotherapy
Foundation hereby announces an international artwork competition, within the framework of which any professional, emerging artist or enthusiast without any age, professional or educational requirements is invited to submit their newly created artwork dedicated to the struggle with oncological disease or victory over it.
In the early twentieth century the idea of the virus being a potential antineoplastic agent was being explored, after observing cases of short lived remissions in cancer patients following viral infections.2 It wasn't until late twentieth century that fundamental understanding of virus was established, thus it was from this point forward that research efforts in establishing Virotherapy
gained momentum,2 which uses a genetically modified virus to treat cancers.
Adenovirus 5 (Ad5) subtype has been extensively used in oncolytic virotherapy
as a vector .
by Recombinant Vaccinia Viruses Coding Apoptosis-Inducing Proteins Delays Growth of Developed Tumor.