The PD-L1 immune checkpoint blockade made stem cell-based oncolytic virotherapy
a better way to deal with melanoma brain metastasis.
e, Head of Aina Muceniece Virotherapy
As such, one of the biggest hurdles in virotherapy
is maintaining a fine balance between oncolytic potential and tumour selectivity.
Recently, at the annual meeting of the American Society of Clinical Oncology, scientists announced the first positive results for virotherapy
in large-scale clinical trials with cancer patients, paving the way for a new class of drugs to be approved for general use.
is expected to prove expensive to carry out.
Aina Muceniece's daughter followed in her mother's footsteps and heads the Association of Virotherapy
of Latvia which aims to promote virotherapy
and the training of doctors to use the medication.
The emerging fields of suicide gene therapy and virotherapy
However, the continued quest for candidate viruses for oncolytic virotherapy
led to the identification of NDV as virus with an inherent oncolytic potential for the treatment of human cancers (15-19).
With help of virotherapy
, the researchers found, that the median survival time of MV-CEA-treated mice almost doubled, and complete tumour regression was observed in one-fifth of treated animals.
Objective: The Viruses, Immune stimulation and RNA Interference in Oncology Network (VIRION) is focused on the execution of an internationally competitive cancer research project focused on the development of a novel therapeutic regime by combining immune therapy with oncolytic virotherapy
and RNA interference techniques.
Medical research in Latvia has shed light on new methods including virotherapy
for treating cancer.