Cryz Jr., "Immunopotentiating reconstituted influenza virus virosome vaccine
delivery system for immunization against hepatitis A," Journal of Clinical Investigation, vol.
The resulting virosome vaccine
can attach to and fuse with host cells, but lacking genetic material, it can't replicate or harm the bird.
A promising alternative that is in an earlier stage of development involves the virosome vaccine
. This trivalent vaccine, consisting of liposomes coated with influenza-derived proteins, has impressive immunogenicity in the elderly, she said.
in December 2013, which will fund the development of a virosome vaccine
technology licensed from Mymetics Corp.
To overcome those problems, Kapcyznski and his colleagues at the Southeast Poultry Research Laboratory in Athens, Georgia, developed what's known as a nonreplicating virosome vaccine.
The virosome vaccine is composed of liposomes, water insoluble spheres encased in lipid layers.
In one study, day-old chicks were divided into three groups: a control group, which received saline solution; a group that received live-virus vaccine; and a group that received the virosome vaccine. Two weeks later, birds were challenged with a lethal dose of the virus.
The next step for Kapczynski and his colleagues is to determine whether the virosome vaccine can protect a typical commercial flock, which is exposed to various production and environmental stresses, such as other illnesses and temperature fluctuations.
The MACIVTVA project, which stands for "Manufacturing process for Cold-chain Independent Virosome-based Vaccines" will run 3.5 years and brings together global expertise in the field of virosome vaccines
, manufacturing, spray drying, freeze drying and analytical techniques from the pharma industry.