The patient was treated with rituximab, cyclophosphamide, epirubicin, vindesine
, and prednisone for 6 courses and remained in partial remission till now.
Kawahara et al., "Phase III study of concurrent versus sequential thoracic radiotherapy in combination with mitomycin, vindesine
, and cisplatin in unresectable stage III non-small-cell lung cancer," Journal of Clinical Oncology, vol.
All but 1 patient had previously received at least 2 other treatments, including chemotherapy for 8, with dacarbazine, carboplatin, temozolomide, vindesine
, fotemustine, or cyclophosphamide; vaccination for 4; anti-CTLA4 antibody ipilimumab for 2 (10 or 3mg/kg for 1 each); NCT00324155 protocol: dacarbazine (850mg/m2 every 3 weeks) + ipilimumab (10mg/kg every 3 weeks) for 2; NCT00338130 protocol comparing AstraZeneca AZD6244 versus temozolomide, radiotherapy delivered to a cutaneous metastasis on the lower limb, and surgery for small intestine resection.
In case of a lack of response to the DTIC therapy, a cisplatin (or its analogues) combined with other cytostatic drugs (carboplatin, nitrourea, taxanes, vindesine
, and vinblastine) may be effective.
The patient underwent 4 cycles of chemotherapy with ABVD (doxorubicin, bleomycin, vindesine
, and dacarbazine).
Neurotoxic Agents by Class Class Medications Bortezomib Cytomib[R], Velcade[R] Platinum compounds Cisplatin (Platinol[R]) Carboplatin (Paraplatin[R]) Oxaliplatin (Eloxatin[R]) Taxanes Paclitaxel (Abraxane[R], Taxol[R]) Docetaxel (Taxotere[R]) Thalidomide, lenalidomide Thalomid[R], REVLIMID[R] Vinca alkaloids Vincristine (Oncovin[R]) Vnblastine Vindesine
Vinorelbine (Navelbine[R]) Source: Naleschinski et al., 2012 TABLE 3.
Invitation to tender: drugs of the l-compositions for treating malignancies (thioguanine, vinblastine, vincristine, vindesine
, vinorelbine, etc.)
Well known examples include Vinca alkaloids (vincristine, vinblastine, vindesine
, vinorelbine), taxanes (paclitaxel, docetaxel), epipodophyllotoxines (etoposide, teniposide), camptothecine and its derivatives (topothecan, irinothecan), and anthracydines (doxorubicin, daunorubicin, epirubicine, idarubicin).
A recent update of randomised trials conducted by the GELA group and others evaluating the efficacy of rituximab in addition to CHOP or intensified CHOP (namely, ACVBP: 75mg/[m.sup.2] doxorubicin and 1200 mg/[m.sup.2] cyclophosphamide on day 1; 2mg/[m.sup.2] vindesine
and 10 mg bleomycin on days 1 and 5; and 60 mg/[m.sup.2] prednisone on days 1-5) demonstrated that the benefit of rituximab is maintained over the years [1-7].
Postoperatively, the patient underwent five courses of chemotherapy with the R-THP-CVP regimen (rituximab, pirarubicin, doxorubicin, hydrochloride, cyclophosphamide hydrate, vindesine
sulfate, and prednisolone).
MVP combination Auricular acupressure 2003  RCT, (mitomycin + vindesine
LongHua Hospital + cisplatin) or NP Affiliated to combination (Navelbine SUTCM, Shanghai, + cisplatin) or FAM China combination (fluorouracil + Adriamycin + mitomycin), and so forth.
Combination chemotherapy with doxorubicin, bleomycin and vindesine
for AIDS-related Kaposi's sarcoma.