vincristine


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Related to vincristine: cyclophosphamide, methotrexate, prednisone

vincristine

 [vin-kris´tēn]
a vinca alkaloid used as an antineoplastic agent, primarily as a component of combination chemotherapy regimens for Hodgkin's disease, acute lymphoblastic leukemia, and non-Hodgkin's lymphomas, as well as in the treatment of other neoplastic disorders including Wilms' tumor, neuroblastoma, AIDS-associated Kaposi sarcoma, and rhabdomyosarcoma. Administered intravenously as the sulfate salt.

vincristine

(vĭn-krĭs′tēn′)
n.
An alkaloid, C46H56N4O10, originally obtained from the Madagascar periwinkle and used in its sulfate form to treat acute leukemia and a variety of other neoplasms.

MOPP

A 4-drug chemotherapy regimen for stage-III Hodgkin lymphoma.
 
Adverse effects
Sterility, nausea, vomiting, immunosuppression, increased infections, myelosuppression, myelodysplasia, ANLL.

vincristine

Oncovin® AIDS A dimeric vinca alkaloid used to treat KS, thrombocytopenia, leukemias, lymphomas, solid tumors and other CAs which, like vinblastine, interrupts the mitotic spindle, causing lysis of proliferating cells Adverse effects Reversible peripheral neuropathy, constipation. Cf Vinblastine.

vincristine

A vinca alkaloid anticancer drug used to treat LEUKAEMIA. The drug is on the WHO official list. A brand name is Oncovin.
References in periodicals archive ?
Five of the 6 patients were retreated with vincristine and all responded to treatment.
Cassady, "Improved outlook for Ewing's sarcoma with combination chemotherapy (vincristine, actinomycin D and cyclophosphamide) and radiation therapy," Cancer, vol.
In patients with RMS, chemotherapy regimens considered in recurrent disease include vincristine, doxorubicin, and cyclophosphamide; ifosfamide and etoposide; and vincristine, irinotecan, and temozolomide [32, 33].
This second theory was assessed by evaluating the effect of BDME on neuropathic pain induced by vincristine. In neuropathic pain model induced by vincristine, NF-kB is activated and the level of TNF-[alpha] increases in the sciatic nerve [49, 50].
At the end of the course of vincristine, 21 patients out of the 54 achieved complete remission.
A, Schedule of cell cycle synchronization showing the time of each cell cycle phase and the double blockade with serum deprivation and vincristine made to analyze the origin of micronuclei according to BrdU-1 and BrdU-2 assays.
In order to check the effect of mogoltacin on cytotoxicity of vincristine, it was necessary to find IC50 of vincristine on TCC cells first.
A therapeutic monoclonal antibody approved as first-line treatment for diffuse large B-cell, CD20-positive, non-Hodgkin's lymphoma (NHL), taken in combination with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) or with other anthracycline-based chemotherapy regimens.
The regimen, known as the Stanford V, involves a combination of doxorubicin, vinblastine, nitrogen mustard, vincristine, bleomycin, etoposide, and prednisone with differing levels of radiation given for 8 or 12 weeks.
The committee will also review Ilex/Enzon's liposomal vincristine formulation Marqibo NDA (21-600) for relapsed aggressive non-Hodgkin's lymphoma and Ilex' Clolar (clofarabine) NDA (21-673) for pediatric patients (1-21 years) with refractory or relapsed acute leukemias on Dec 1.
Cancer-fighting weed derivatives include vinblastine for Hodgkin's disease and vincristine for childhood leukemia, reports John Richard Stepp, a University of Florida anthropologist, in the Journal of Ethno-Pharmocology.