vinca alkaloids


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Related to vinca alkaloids: vinblastine, vincristine, paclitaxel, Taxanes

vinca alkaloids

 [vin´kah]
a group of cytotoxic alkaloids extracted from the Madagascar periwinkle (Catharanthus roseus G. Don or Vinca rosea L.) and used as antineoplastic agents; they are cell cycle specific for the M phase of cell division and disrupt the microtubules that form the spindle apparatus. The group includes vinblastine, vincristine, vindesine, and vinorelbine tartrate.

Vinca al·ka·loids

alkaloids such as vincristine and vinblastine (antitumor agents) extracted from the periwinkle plant.

vinca alkaloids

A class of cytotoxic drugs used to treat various cancers. Examples are vindesine (Eldisine), vincristine (Oncovin) and vinblastine (Velbe).
References in periodicals archive ?
Asima Chatterjee's work in the field of science opened the doors for millions of women to excel in the field and her research on vinca alkaloids which is now widely used in chemotherapy and helps to slow down the growth rate of cancer cells.
In 1976, Potier's team discovered that the Tubulin test proved a semi-synthesis of one vinca alkaloid compound to be active, showing promise as an anticancer drug.
The plant provides the starting compounds for the family of drugs known as vinca alkaloids which are widely used in cancer treatment.
Taxol and anti-cancer agents from ornamental shrubs (called vinca alkaloids) affect the cancer cells internal skeleton, making cell division unsuccessful, while marine sponge and fungus compounds attack cancer via other mechanisms.
ATMs belong to a class of anti-cancer drug known as anti-mitotics, including the current taxanes and vinca alkaloids.
Several drugs currently used in chemotherapy were isolated from plant species.The best known are the Vinca alkaloids, vinblastine and vincristine, isolated from Catharanthus roseus, etoposide and teniposide, which are semi-synthetic derivatives of the natural product epipodophyllotoxin, Paclitaxel isolated from the bark of Taxus brevifolia, the semi-synthetic derivatives of camptothecin, irinotecan and topotecan, isolated from Cam ptotheca acuminata, among several others (Cragg et al.
Cancer patients treated with taxanes, vinca alkaloids, or platinum compounds can develop a condition known as chemotherapy induced peripheral neuropathy, or CIPN for short, as a by-product of their treatment.
Strong evidence and guidelines developed by a consensus panel of experts recommend a proactive approach to preventing constipation in patients at highest risk, particularly those receiving medications such as vinca alkaloids, which slow colonic transit times, or opioids.