Pharmacokinetic drug interactions of vinca alkaloids
: summary of case reports.
Chatterjee's most noted contribution to the field, however, was her work on vinca alkaloids
. Alkaloids are compounds made from plants, often to treat medical ailments.
The taxanes and vinca alkaloids
target that part of the cytoskeleton known as microtubules.
The concomitant use of stavudine or didanosine with vinca alkaloids
, taxanes and ifosfamide may increase the risk of peripheral neuropathy.
Since their introduction over 40 years ago, anti-mitotic drugs (taxanes and vinca alkaloids
) have advanced the treatment of cancer and are commonly used for the treatment of several tumor types.
Chemotherapy Agents Associated With Neurotoxicity Combination of methotrexate, * cyclophosphamide, and fluorouracil * Vinca alkaloids
Cytarabine Platinum analogues Ifosfamide Taxol Taxotere Fludarabine Suramin Agents Associated With Occasional Reports of Cognitive or Motor Impairment L-asparagine Busulfan Hexamethylmelamine Procarbazine Thiotepa * Also associated with cognitive impairment individually.
Suspect Drugs Chemotherapy Agents Associated With Neurotoxicity Combination of methotrexate*, cyclophosphamide, and fluorouracil* Vinca alkaloids
Cytarabine Platinum analogues Ifosfamide Taxol Taxotere Fludarabine Suramin Agents Associated With Occasional Reports of Cognitive or Motor Impairment L-asparagine Busulfan Hexamethylmelamine Procarbazine Thiotepa *Also associated with cognitive impairment individually.
The plant provides the starting compounds for the family of drugs known as vinca alkaloids
which are widely used in cancer treatment.
Taxol and anti-cancer agents from ornamental shrubs (called vinca alkaloids
) affect the cancer cells internal skeleton, making cell division unsuccessful, while marine sponge and fungus compounds attack cancer via other mechanisms.
Several drugs currently used in chemotherapy were isolated from plant species.The best known are the Vinca alkaloids
, vinblastine and vincristine, isolated from Catharanthus roseus, etoposide and teniposide, which are semi-synthetic derivatives of the natural product epipodophyllotoxin, Paclitaxel isolated from the bark of Taxus brevifolia, the semi-synthetic derivatives of camptothecin, irinotecan and topotecan, isolated from Cam ptotheca acuminata, among several others (Cragg et al.
Cancer patients treated with taxanes, vinca alkaloids
, or platinum compounds can develop a condition known as chemotherapy induced peripheral neuropathy, or CIPN for short, as a by-product of their treatment.
Strong evidence and guidelines developed by a consensus panel of experts recommend a proactive approach to preventing constipation in patients at highest risk, particularly those receiving medications such as vinca alkaloids
, which slow colonic transit times, or opioids.