* VPV regimen: vinblastine
, cisplatin, and etoposide.
has been reported among others to be successful in patients with aggressive disease .
Table 1 Inhibition of vinblastine
(VIN) and paclitaxel (PTX) as a single agent and its potentiation by L-canavanine (L-CAV) toward growth of human cancer cells.
The pathways responsible for making many of periwinkle's alkaloids, including vinblastine
, are so elaborate that scientists have worked out few of the specifics.
c) Arjunic acid in Terminalia is a less active cytotoxic agent than vinblastine
PUVA and topical nitrogen mustard seem to be most effective for the skin lesions while vinblastine
or etoposide have been used for the systemic manifestations (J.
As palliative treatment, he received 4x10 mg vinblastine
for his residual disease.
Agents used included doxorubicin, cyclophosphamide, pad taxel, bleomycin, cisplatin, and vinblastine
. The mean number of treatments was 4.4, said Dr.
For example, as recently as the 1980s, the plant rosy periwinkle (Catharanthus roseus) gave rise to two important drugs, vinblastine
and vincristine, which are used to treat Hodgkin's disease and childhood leukemia, respectively.
But right now, drug companies must harvest the anticancer substances, vinblastine
and vincristine, from the plant itself.
- US-based Seattle Genetics, Inc.'s (NASDAQ: SGEN) collaborator, Takeda Pharmaceutical Company Ltd., has received approval from the European Commission to extend the marketing authorisation for Adcetris (brentuximab vedotin) to include Adcetris in combination with AVD (Adriamycin, vinblastine
and dacarbazine) in adults patients with previously untreated CD30+ stage IV classical Hodgkin lymphoma.
Contract awarded for :medicines atc l01 - cytostatics (vinblastine