vinblastine


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Related to vinblastine: vincristine

vinblastine

 [vin-blas´tēn]
a vinca alkaloidantineoplastic agent that causes metaphase arrest during cell mitosis by damaging the mitotic spindles. It is used primarily in combination chemotherapy regimens for testicular carcinoma and Hodgkin's lymphomas, choriocarcinoma, breast carcinoma, and histiocytosis X. Available as vincristine sulfate, administered intravenously.

vinblastine

(vĭn-blăs′tēn′)
n.
An alkaloid, C46H58N4O9, originally obtained from the Madagascar periwinkle and used in the form of its sulfate as an antineoplastic drug.

M VAC

A chemotherapeutic regimen for advanced urothelial (bladder) cancer, which has a reported 36% response rate.

vinblastine

Oncology An IV vinca alkaloid used with other agents to treat Hodgkin's disease, leukemia, and other lymphoproliferative disorders, KS, CAs Adverse effects BM toxicity, neuropathy

vinblastine

An anticancer drug used mainly in the treatment of HODGKIN'S DISEASE and other LYMPHOMAS. The drug is on the WHO official list. A brand name is Velbe.
References in periodicals archive ?
* VPV regimen: vinblastine, cisplatin, and etoposide.
Vinblastine has been reported among others to be successful in patients with aggressive disease [5].
Table 1 Inhibition of vinblastine (VIN) and paclitaxel (PTX) as a single agent and its potentiation by L-canavanine (L-CAV) toward growth of human cancer cells.
The pathways responsible for making many of periwinkle's alkaloids, including vinblastine, are so elaborate that scientists have worked out few of the specifics.
c) Arjunic acid in Terminalia is a less active cytotoxic agent than vinblastine.
PUVA and topical nitrogen mustard seem to be most effective for the skin lesions while vinblastine or etoposide have been used for the systemic manifestations (J.
As palliative treatment, he received 4x10 mg vinblastine for his residual disease.
Agents used included doxorubicin, cyclophosphamide, pad taxel, bleomycin, cisplatin, and vinblastine. The mean number of treatments was 4.4, said Dr.
For example, as recently as the 1980s, the plant rosy periwinkle (Catharanthus roseus) gave rise to two important drugs, vinblastine and vincristine, which are used to treat Hodgkin's disease and childhood leukemia, respectively.
But right now, drug companies must harvest the anticancer substances, vinblastine and vincristine, from the plant itself.
- US-based Seattle Genetics, Inc.'s (NASDAQ: SGEN) collaborator, Takeda Pharmaceutical Company Ltd., has received approval from the European Commission to extend the marketing authorisation for Adcetris (brentuximab vedotin) to include Adcetris in combination with AVD (Adriamycin, vinblastine and dacarbazine) in adults patients with previously untreated CD30+ stage IV classical Hodgkin lymphoma.
Contract awarded for :medicines atc l01 - cytostatics (vinblastine)