vimentin


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vi·men·tin

(vī-men'tin), [MIM*193060]
The major polypeptide that copolymerizes with other subunits to form the intermediate filament cytoskeleton of mesenchymal cells; may have a role in maintaining the internal organization of certain cells.
See also: desmins.
Farlex Partner Medical Dictionary © Farlex 2012

vi·men·tin

(vī-men'tin)
The major polypeptide that copolymerizes with other subunits to form the intermediate filament cytoskeleton of mesenchymal cells; may have a role in maintaining the internal organization of some cells.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
Immunohistochemically, the adenocarcinoma showed positive staining for cytokeratin and carcinoembryonic antigen, and the osteosarcoma showed positive staining for vimentin (Figure 3).
Immunohistochemical study of neoplastic cells showed diffuse strong positivity for vimentin (Fig.
We used immunostaining for vimentin (clone V9, Dako, 1:50) and alpha smooth muscle actin (clone 1A4, Dako, 1:100), revealing intense and diffuse cytoplasmic stainingof the neoplastic cells for both vimentin (Figure 1D) and alpha smooth muscle actin (Figure 1E).
The round stromal cells were positive for thyroid transcription factor-1 (TTF-1) and vimentin but negative for epithelial membrane antigen (EMA) and pan-Cytokeratin, and the cuboidal surface cells were positive for TTF-1, vimentin, EMA, Ki-67, and pan-Cytokeratin [Figure 1]d,[Figure 1]e,[Figure 1]f,[Figure 1]g,[Figure 1]h.{Figure 1}
Immunohistochemistry (IHC) reveals expression of vimentin, but not cytokeratins, epithelial membrane antigen, carcinoembryonic antigen, desmin, [alpha]-fetoprotein, [[alpha].sub.1]-antitrypsin, type 4 collagen, caldesmon, S100, Melan-A, synaptophysin, chromogranin, CD99, estrogen receptor, androgen receptor, or testosterone.
Neoplastic cells were positive for S100, HMB-45, and vimentin. The BRAF mutation was not detected.
Pathologic examination showed the mass to be positive for vimentin, cytokeratin, and actin, and negative for TTF-1, thyroglobulin, CD34, and EM A (figure 2).
They discovered that their probe, named TiY (for tumor-initiating cell probe yellow), recognizes vimentin, which is a molecule in the cytoskeleton.
Vimentin was detected in Sertoli cells by the procedure which was described by Tajik et al (17).
Therefore, the panel of markers included CD117, DOG1 and CD34 for gastrointestinal stromal tumor (GIST), CK AE1/AE3, CK5, CK7, CK20, TTF-1 and p63 for carcinoma of digestive, pulmonary or squamous origin, Synaptophysin and Chromogranin A for neuroendocrine neoplasia, S100, Melan-A and HMB45 for malignant melanoma, HSA for hepatocellular carcinoma or hepatoblastoma, Vimentin and SMA for sarcoma and Ki-67 to evaluate the mitotic activity.
Immunohistochemistry was positive for vimentin and synaptophysin [Figure 2] while negative for pan-Cytokeratin (panCK), P-40, S-100, epithelial membrane antigen (EMA), chromogranin, melan-A, desmin, smooth muscle actin (SMA), neuron-specific enolase, CD99, CD56, CD20, CD45, and glial fibrillary acid protein (GFAP), thus confirming ESMC.
To test this, the expression of the epithelial marker E-cadherin and the mesenchymal marker vimentin was analyzed using QRT-PCR and Western blotting assays.