villous atrophy


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vil·lous at·ro·phy

abnormality of the small intestinal mucosa with crypt hyperplasia, resulting in flattening of the mucosa and the appearance of atrophy of villi; clinically seen in malabsorption syndromes such as sprue.

villous atrophy

Flattening and disappearance of the finger-like absorptive processes of the small intestine that is a feature of COELIAC DISEASE. Villous atrophy is associated with an increased density of LYMPHOCYTES in the bowel lining (intraepithelial lymphocytes), but whether they cause it is uncertain.
References in periodicals archive ?
pylori and showed more severe intestinal damage, including complete villous atrophy; these results were also reported by Villanacci et al.
Definition of Small Bowel Villous Atrophy. The duodenal mucosal pathology was evaluated by an experienced pathologist and was used as the gold standard for the diagnosis of villous atrophy.
Decreased maltase and sucrase activities thus have a high positive predictive value for the degree of mucosal villous atrophy. Predictive values of lactase activity are lower, probably due to the presence of primary lactase deficiency in coeliac patients.
reported a fatal case report of a young woman who developed DRESS from antiepileptic drugs with subsequent HLH diagnosed about 5 months after her initial presentation; with endoscopy biopsies that revealed marked villous atrophy in the duodenum with absence of goblet and Paneth cells in the duodenum and colon [2].
The initial investigations for CD revealed positive values for TG and EMAs, and intestinal biopsy showed total villous atrophy associated with an increased number of intraepithelial lymphocytes and crypt hyperplasia in the mucosa consistent with a diagnosis of CD.
The characteristic histological features of mucosal inflammation, villous atrophy, crypt hyperplasia, and lymphocyte infiltration of the epithelium confirm the diagnosis (Runge & Nguyen, 2010).
Jejunal villous atrophy with morbid obesity: death after jejunoileal bypass.
More importantly, duodenal biopsy revealed villous atrophy and crypt hyperplasia.
Strain CV777 infections caused intestinal villous atrophy with substantially reduced ratios of villous height to crypt depth (VH:CD) (3,4).
Drug-and autoimmune-induced enteropathy have similar presentations, including severe chronic diarrhea; villous atrophy and collagen deposition with or without intraepithelial lymphocytes; and negative tissue transglutaminase antibodies and endomysial antibodies.
It showed villous atrophy and cyclospora infestation without any evidence of celiac disease.
An esophagogastroduodenoscopy with histological examination showed "stage IV of Marsh villous atrophy" (Fig.