The most frequently identified placental histopathologic abnormality of congenital CMV is lymphoplasmacytic chronic villitis
. (13-15) Examination of villi may reveal the characteristic cytomegaly with intranuclear and intracytoplasmic inclusions (Figure 1, A and B).
Placental disorders such as placentomegaly, chronic villitis
, acute chorioamnionitis, amnion nodosum, and placenta previa have also been reported in association with chorangiosis (1,3).
Ademas encontraron una correlacion significativa entre el peso al nacer y las diferentes caracteristicas patologicas en las vellosidades del tallo como el numero, estrechamiento arterial, cambios degenerativos y villitis
. Tambien identificaron una correlacion significativa entre el peso neonatal al nacer y el numero de capilar velloso terminal pero no encontraron una correlacion significativa entre el peso al nacer y los cambios fibroticos vellosos terminales.
In several countries an increasingly recognised example of abortion and stillbirth due to a diffuse placental villitis
is that caused by a number of different leptospiral serovars.
 Placental malaria can produce pathological changes in the placenta, such as thickening of the basement membrane, inflammatory cell infiltrates, villitis
and microinfarct owing to clumping of parasitised red blood cells and the occlusion of micro vasculatures.
 The discrete histopathological findings were grouped into 15 main findings and four major pathological patterns for the purpose of statistical analysis:  (i) maternal vascular underperfusion (MUP) including non-marginal, recent, and organised infarction involving >10% of parenchyma, agglutination, placental syncytial (ST) knots, intervillous fibrin deposition involving more than 20% of the intervillous space, peri-villous fibrin deposition, villous hypoplasia, intervillous haematoma or retroplacental haematoma; (ii) fetal vascular underperfusion (FUP) including fetal vasculopathy and/or avascular villi; (iii) inflammatory with villitis
, chorioamnionitis or vasculitis lesions; (iv) others (stromal fibrosis and calcification).
Features of chronic villitis
were detected in 3 of the IUGR placentas and 1 of the control placenta and the difference was not significant (p 0.2).
We posited that damage to the placenta may occur directly from exposure to circulating particles or secondary to systemic inflammation, either of which may result in any of the well-defined histologic placental chronic inflammatory lesions--chronic villitis
(Figure 1), chronic chorioamnionitis, or intervillositis.
Philippe, "Placental candidiasis: Report of four cases, one with villitis
," APMIS-Acta Pathologica, Microbiologica etImmunologica Scandinavica, vol.
Pathological analysis of the debris from the conceptus revealed chorioamnionitis, necrotizing deciduitis, and villitis
. Gram stain on formalin fixed paraffin embedded tissue identified numerous Gram-negative bacilli within the chorionic villi and the placental membranes (Figure 1).
Histopathologic findings considered contributory to FGR included the following: increased syncytial knots, villous agglutination, increased intervillous fibrin, distal villous hypoplasia, acute atherosis, mural hypertrophy in membrane arterioles, muscularization of basal plate arteries, increased placental site giant cells in decidua basalis, immature intermediate trophoblast in decidua basalis, thin umbilical cord (diameter of the umbilical cord [less than or equal to] 8 mm), uniformly avascular villi, villous stromal-vascular karyorrhexis, villitis
of unknown etiology (VUE) with obliterative fetal vasculopathy, large fetal vessel thrombosis, fetal intimal fibrin cushion, chorangiosis, nucleated red cells in capillaries, and VUE.
Placental tissue from one miscarriage showed heterogeneous chorionic villi with calcification, fibrosis, perivillous fibrin deposition, and patchy intervillositis and focal villitis
, while tissue from the other miscarriage had sparsely sampled normal-appearing chorionic villi.