villin


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vil·lin

(vil'in), [MIM*193040]
An actin-binding protein that, at low calcium ion concentrations, nucleates polymerization of actin filaments; micromolar Ca2+ causes villin to sever actin filaments into short fragments.

villin

An actin-binding, severing and bundling protein found in the MICROVILLI of the apical membranes of certain cells, including the canalicular microvilli of hepatocytes. Abnormalities in the expression of the gene for villin, resulting in the absence of this protein are thought to be a cause of such liver disorders as biliary atresia.

villin

a protein binding the actin filaments of microvillar cores.
References in periodicals archive ?
Initial immunohistochemical workup demonstrated the tumor cells to be diffusely positive for AE1/AE3; patchy positive for calretinin; and negative for CK7, CK20, CDX2, villin, CD45, S100, PAX8, and synaptophysin.
Although the individual sensitivities of CDX2 and villin as markers of the latter tumors are each approximately 50%, their combined sensitivity is in excess of 75%.
28, 29) For the 18 MC cases, staining for MSI markers (MLH1, PMS2, mutS homolog 2 (MSH2), mutS homolog 6 (MSH6), CDH17, SATB2, CDX2, CK7, CK20, TFF3, MUC4, calretinin, P504S, villin, and synaptophysin were performed.
C and D, Immunoreactivity for cytokeratin 7 and villin, respectively, is indicative of an upper gastrointestinal tract phenotype (hematoxylin-eosin, original magnifications X40 [A and B]; original magnifications X100 [C and D]).
Benign and malignant ovarian mucinous tumors associated with mature cystic teratomas may show massive mucin secretion, goblet cells, carcinoid-like patterns, pseudomyxoma ovarii and peritonei, and signet ring cells characteristic of a gastrointestinal phenotype, with markers such as CDX2, HepPar-1 and villin, as well as a cytokeratin 7-negative/ cytokeratin 20-positive profile.
The immunohistochemical panel used to distinguish primary vesical adenocarcinoma from metastatic colonic adenocarcinoma includes cytokeratin (CK) 7, CK20, 34[beta]E12, thrombomodulin, villin, CDX-2, and [beta]-catenin.
Both goblet and nongoblet glandular (cardiac-type) epithelial cells within the distal esophagus show immunohistochemical evidence of intestinal differentiation and express CDX2, MUC2, and villin.
18-24) For example, metaplastic non-goblet cell columnar epithelium reveals positivity for markers such as CDX-2, DAS-1, villin, and HepPar1, all of which are also expressed in intestinalized epithelium throughout the gastrointestinal tract, including esophageal IM.
The sample was negative for staining with villin, TTF-1, CDX2, S100 protein, vimentin, gross cystic disease fluid protein 15, mammoglobulin, and MUC2.
76) Genetic analysis had initially ruled out a role for the fibronectin, desmin, villin, and uteroglobin genes.
40) Similar to pCEA, villin and CD10 also show a canalicular pattern of staining.
A particular subtype of lung adenocarcinoma, not included in the WHO classification, is clearly emerging as a specific entity defined on the basis of its peculiar intestinal phenotype and in particular the expression of the transcription factor cdx-2, variably accompanied by other markers of intestinal differentiation including CK20, villin, and MUC2.