vidarabine


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Related to vidarabine: didanosine, Cidofovir, Trifluridine

vidarabine

 [vi-dar´ah-bēn]
adenine arabinoside (ara-A), a purine analogue that inhibits DNA synthesis; used as an antiviral agent to treat herpes simplex keratitis and keratoconjunctivitis.

vi·dar·a·bine

(vī-dar'ă-bēn),
A purine nucleoside obtained from fermentation cultures of Streptomyces antibioticus used to treat herpes simplex infections.

vidarabine

/vi·dar·a·bine/ (vi-dar´ah-bēn) adenine arabinoside (ara-A), a purine analogue that preferentially inhibits viral DNA synthesis; used as an antiviral agent to treat herpes simplex keratitis or keratoconjunctivitis.

vidarabine

[vider′əbēn]
an antiviral agent. Also called adenine arabinoside.
indications This drug is an ophthalmic ointment prescribed to treat keratoconjunctivitis and nearby epithelial or superficial keratitis caused by herpes simplex virus type 1 or type 2.
contraindications Known hypersensitivity to this drug prohibits its use, and it should not be used for ophthalmic ulcers that are sterile.
adverse effects Local irritation, photophobia, and corneal edema may occur in topical ophthalmic applications.

vidarabine

Ara-A Virology An IV or topical antiviral active against DNA viruses; it is a competitive inhibitor of DNA-dependent DNA polymerase, and ↓ mortality of neonatal HSV, HSV encephalitis Toxicity Thrombocytopenia, leukopenia, N&V, diarrhea, irritability, tremors, ataxia, paresthesias, hallucinations, ↓ renal, liver function

vi·dar·a·bine

(vī-dar'ă-bēn)
A purine nucleoside obtained from fermentation cultures of Streptomyces antibioticus used to treat herpes simplex infections.

vidarabine

A drug that inhibits DNA synthesis and is used to treat Herpes simplex infections.

antiviral agents 

Substances which inhibit the growth of a virus (e.g. herpes) by inhibiting DNA or RNA synthesis. Common agents include aciclovir (acyclovir), idoxuridine, ganciclovir, trifluoridine (trifluorothymidine) and vidarabine. See herpetic keratitis; virus.

vi·dar·a·bine

(vī-dar'ă-bēn)
Purine nucleoside used to treat herpes simplex infections.

vidarabine (vidar´əbēn´),

n (ophthalmic),
brand name: Vira-A Ophthalmic;
class: antiviral;
action: inhibits DNA synthesis by blocking DNA polymerase;
use: keratoconjunctivitis due to herpes simplex virus.

vidarabine

a purine analog, adenine arabinoside (ara-A), that inhibits DNA synthesis; used as an antiviral agent to treat herpesvirus infection.
References in periodicals archive ?
With the rapid spread of viral hepatitis and other diseases in the world, the demand for therapeutic drug has increased sharply in recent years, which promotes the rapid development of vidarabine monophosphate market.
The overall production capacity of China's vidarabine monophosphate was estimated to be about CNY 100 million in 2011.
Market status of Vidarabine Monophosphate for Injection in Chinese Hospitals
Product Overview of China's Vidarabine Monophosphate Product
Successful vidarabine therapy for adenovirus type 11-associated acute hemorrhagic cystitis after allogeneic bone marrow transplantation.
Immunosuppressed individuals may be treated with acyclovir, interferonalpha, and vidarabine.
Sequential vidarabine infusion in the treatment of polyoma virus-associated acute haemorrhagic cystitis late after allogeneic bone marrow transplantation.
In a study comparing acyclovir to vidarabine, there was no difference in mortality based on the drug used.
SRI's own drug discoveries include the anti-malarial halofantrine (Halfan(R)), the antiviral vidarabine (Vira-A), several agents in human clinical trials for cancer treatment and diagnosis, and several small-molecule drug candidates about to enter clinical development for cancer treatment.
For example, adenovirus-associated HLH in a bone marrow transplant patient was reported to resolve with vidarabine (73), while human herpesvirus-8-associated HLH in a patient with HIV infection appeared to improve with the use of foscarnet (74).
Vidarabine versus acyclovir therapy of neonatal herpes simplex virus, HSV, infection [abstract #986].
SRI's drug discoveries include the anti-malarial halofantrine (Halfan(R)), the antiviral vidarabine (Vira-A), several agents in human clinical trials for cancer, and several small-molecule drug candidates about to enter clinical development for cancer treatment and diagnosis.