vidarabine


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Related to vidarabine: didanosine, Cidofovir, Trifluridine

vidarabine

 [vi-dar´ah-bēn]
adenine arabinoside (ara-A), a purine analogue that inhibits DNA synthesis; used as an antiviral agent to treat herpes simplex keratitis and keratoconjunctivitis.

vi·dar·a·bine

(vī-dar'ă-bēn),
A purine nucleoside obtained from fermentation cultures of Streptomyces antibioticus used to treat herpes simplex infections.

vidarabine

Ara-A Virology An IV or topical antiviral active against DNA viruses; it is a competitive inhibitor of DNA-dependent DNA polymerase, and ↓ mortality of neonatal HSV, HSV encephalitis Toxicity Thrombocytopenia, leukopenia, N&V, diarrhea, irritability, tremors, ataxia, paresthesias, hallucinations, ↓ renal, liver function

vi·dar·a·bine

(vī-dar'ă-bēn)
A purine nucleoside obtained from fermentation cultures of Streptomyces antibioticus used to treat herpes simplex infections.

vidarabine

A drug that inhibits DNA synthesis and is used to treat Herpes simplex infections.

antiviral agents 

Substances which inhibit the growth of a virus (e.g. herpes) by inhibiting DNA or RNA synthesis. Common agents include aciclovir (acyclovir), idoxuridine, ganciclovir, trifluoridine (trifluorothymidine) and vidarabine. See herpetic keratitis; virus.

vi·dar·a·bine

(vī-dar'ă-bēn)
Purine nucleoside used to treat herpes simplex infections.
References in periodicals archive ?
For example, physicochemical properties of vidarabine were evaluated using brand-name drugs, generic drugs, and switch OTC drugs, and differences in the viscosity of each formulation due to differences in additives in the formulation were reported [5].
A number of antiviral drugs, including ribavirin, vidarabine, and cidofovir, have been used to treat adenoviral infections such as Ad14, but none have shown definitive efficacy against adenoviruses (2).
That's because treatment with acyclovir or vidarabine is lifesaving--and without it, one-half of affected mothers will die of fulminant hepatitis, stressed Dr.
Today, in the treatment of herpes virus infections, antiviral drugs like 5-iodo-2-deoxyviridine, cytarabine, vidarabine, and fluorothymidine are used (Corey and Spear, 1986; Crumpacker et al., 1982; Fahad and Stepher, 1996).
Certain drugs have been proposed for the treatment of FeHV-1 ocular infections, including bromovinyldeoxyuridine, cidofovir, famciclovir, N-(2-hydroxy propyl) methacrylamide (HPMA), penciclovir, ribavirin, valacyclovir, vidarabine, foscarnet and lactoferrin (MALIK et al., 2009).
With no proven treatment, various medications, including ribavirin (30), cidofovir (31) and vidarabine (32), and IVIG (33), have been used to treat immunocompromised patients who have severe adenovirus infection; results have been inconsistent.
Immunosuppressed individuals may be treated with acyclovir, interferonalpha, and vidarabine. In this population the live, attenuated vaccine is safer and is preferred to the varicella zoster immunoglobulins (VZIG).
Sequential vidarabine infusion in the treatment of polyoma virus-associated acute haemorrhagic cystitis late after allogeneic bone marrow transplantation.
In a study comparing acyclovir to vidarabine, there was no difference in mortality based on the drug used.
For example, adenovirus-associated HLH in a bone marrow transplant patient was reported to resolve with vidarabine (73), while human herpesvirus-8-associated HLH in a patient with HIV infection appeared to improve with the use of foscarnet (74).