5-O-D-VALYL ara A, A potential prodrug for improving oral biovailability of the antiviral agent vidarabine
, National Institute of Health, v.
For example, physicochemical properties of vidarabine
were evaluated using brand-name drugs, generic drugs, and switch OTC drugs, and differences in the viscosity of each formulation due to differences in additives in the formulation were reported .
Burman et al., "Acyclovir versus vidarabine
in herpes simplex encephalitis.
A number of antiviral drugs, including ribavirin, vidarabine
, and cidofovir, have been used to treat adenoviral infections such as Ad14, but none have shown definitive efficacy against adenoviruses (2).
That's because treatment with acyclovir or vidarabine
is lifesaving--and without it, one-half of affected mothers will die of fulminant hepatitis, stressed Dr.
Today, in the treatment of herpes virus infections, antiviral drugs like 5-iodo-2-deoxyviridine, cytarabine, vidarabine
, and fluorothymidine are used (Corey and Spear, 1986; Crumpacker et al., 1982; Fahad and Stepher, 1996).
Certain drugs have been proposed for the treatment of FeHV-1 ocular infections, including bromovinyldeoxyuridine, cidofovir, famciclovir, N-(2-hydroxy propyl) methacrylamide (HPMA), penciclovir, ribavirin, valacyclovir, vidarabine
, foscarnet and lactoferrin (MALIK et al., 2009).
With no proven treatment, various medications, including ribavirin (30), cidofovir (31) and vidarabine
(32), and IVIG (33), have been used to treat immunocompromised patients who have severe adenovirus infection; results have been inconsistent.
Immunosuppressed individuals may be treated with acyclovir, interferonalpha, and vidarabine
. In this population the live, attenuated vaccine is safer and is preferred to the varicella zoster immunoglobulins (VZIG).
infusion in the treatment of polyoma virus-associated acute haemorrhagic cystitis late after allogeneic bone marrow transplantation.
In a study comparing acyclovir to vidarabine
, there was no difference in mortality based on the drug used.
For example, adenovirus-associated HLH in a bone marrow transplant patient was reported to resolve with vidarabine
(73), while human herpesvirus-8-associated HLH in a patient with HIV infection appeared to improve with the use of foscarnet (74).