vicious viscous hypothesis

vicious viscous hypothesis

Kinetic hypothesis Hematology A hypothesis that attempts to explain the pathogenesis of the microvascular occlusions typical of sickle cell anemia; according to VVH, the ↑ in blood viscosity caused by the relatively inelastic sickled RBCs, slows blood flow in
the microcirculation; this slowing results in relative hypoxia, which favors further sickling of upstream RBCs, resulting in vascular occlusion and infarction
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.