On the other hand, the vials
which are used are of substandard glass and do not conform to any international standard.
The new vial
presentation of the product will be available for use in 300mcg/1mL and 480mcg/1.6mL single-dose vials
IDELVION is currently available in 250 IU, 500 IU, 1000 IU, and 2000 IU, with the 3500 IU vial
to be available for order in the coming weeks.
The design of adaptiQrm is based on a nest-and-tub configuration that overcomes the major roadblock that has prevented a ready-to-fill vial
system in the past: Each vial
must be easily and safely removed from the nest for certain processing steps.
According to the company, sterile use of multi-dose vials
can reduce waste because the vial
's entire contents can be utilised over time.
Due to potential element-leaching that may have occurred in the delamination process, a comparison of the chemistries between the flakes and the vial
glass/vial coating may not produce reliable comparative data, but the elemental composition of the flakes can be used to confirm if they are glasslike material.
The Crystal[R] Closed Vial
Filling System (CVFS) technology consists of a ready-to-fill vial
which is supplied clean and sterile to the pharmaceutical manufacturer.
Sterile use of multi-dose vials
can reportedly reduce waste because the vial
's entire contents can be utilised over time, as opposed to single-dose vials
, which require clinicians to discard the unused volume of solution after drawing up the patient's specific dose.
If we assume that an average product is worth $10 for each recalled filled vial
, this would mean that American drug makers lost $1 billion in revenue (2).
To address the incidents that are still recorded each year due to the injection of contaminated products, and the complexities of vial
component preparation, high-speed stoppering, and aluminum cap crimping, Aseptic Technologies, a subsidiary of GlaxoSmithKline Biologicals, developed the new Crystal[R] Closed Vial
technology for aseptic filling of injectable products.