vesicular stomatitis

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Related to vesicular stomatitis: Vesicular stomatitis virus

ve·sic·u·lar sto·ma·ti·tis

a vesicular disease of horses, cattle, swine, and occasionally humans caused by a Vesiculovirus (vesicular stomatitis virus) in the family Rhabdoviridae; in horses and cattle, the disease usually causes mouth vesicles, that, in cattle, cannot be differentiated clinically from those of foot-and-mouth disease.
Farlex Partner Medical Dictionary © Farlex 2012

vesicular stomatitis

An acute infectious disease of cattle, swine, and horses resembling foot-and-mouth disease, caused by any of several rhabdoviruses of the genus Vesiculovirus, thought to be transmitted by biting insects.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.


(sto-ma-tit'is) [ stomato- + -itis]
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STOMATITIS: As caused by herpes simplex virus
Inflammation of the mouth (including the lips, tongue, and mucous membranes). See: illustration; noma; thrush


Stomatitis may be associated with viral infections, chemical irritation, radiation therapy, mouth breathing, paralysis of nerves supplying the oral area, chemotherapy that damages or destroys the mucous membranes, adverse reactions to other medicines, or acute sun damage to the lips. The nasal and oral mucosa are esp. vulnerable to trauma from dental appliances, nasal cannula, nasotracheal tubes, or catheters administering nutrients. These areas may also be damaged during surgery when an endotracheal tube is in place.


Symptoms include oral pain, esp. when eating or drinking, bad breath, or difficulty in swallowing. Findings include oral ulcers, friability of the mucous membranes, swollen cervical lymph nodes, and sometimes fever.

Patient care

Treatment depends on the cause but is often symptomatic. The mucous membranes should be kept moist and clear of tenacious secretions. Care of the teeth and gingival tissues should be comprehensive and include flossing. The pain of stomatitis may be alleviated by systemic analgesics or application of anesthetic preparations to painful lesions. It is important for patients with dentures to clean their dentures thoroughly. Dentures should be removed from unconscious or stuporous patient. See: toothbrushing

aphthous stomatitis

Aphthous ulcer.

corrosive stomatitis

Stomatitis resulting from intentional or accidental exposure to corrosive substances.

denture stomatitis

Stomatitis on the oral mucosa covered by full or partial dentures, most commonly seen on the palate although the inflammation may also be seen overlying the mandible.

Patient care

Although most patients are asymptomatic (the finding is noticed by dental professionals during oral examination, rather than by the patient), the condition should be treated to prevent progression to more serious oral diseases. Removal of plaque from dentures (as by brushing them carefully), removal of dentures at night, and sanitizing dentures regularly (as with an overnight soak in a chlorhexidine solution) all prevent the condition from occurring. Antifungal medications are used if fungi are isolated on culture swabs.

Synonym: chronic atrophic candidiasis

diphtheritic stomatitis

Stomatitis caused by infection with Corynebacterium diphtheriae.
See: diphtheria

herpetic stomatitis

Stomatitis seen with primary infection with herpes simplex virus.

major aphthous stomatitis

Stomatitis in which large recurring or migrating painful ulcers appear within the oral cavity (on the gingiva and soft palate) and sometimes on the lips.

membranous stomatitis

Stomatitis accompanied by the formation of a false or adventitious membrane.

mercurial stomatitis

Stomatitiss seen in those exposed to elemental mercury or mercury vapors.

mycotic stomatitis


nicotine stomatitis

, stomatitis nicotina
Fissuring and the formation of hyperkeratotic papules on the palate, usually caused by habitual pipe smoking. It is a form of precancer.

simple stomatitis

Stomatitis occurring in patches on the mucous membranes.

traumatic stomatitis

Stomatitis resulting from mechanical injury as from ill-fitting dentures, sharp jagged teeth, or biting the cheek.

ulcerative stomatitis

Necrotizing ulcerative gingivitis.

vesicular stomatitis

Aphthous ulcer.

Vincent stomatitis

Necrotizing ulcerative gingivitis.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Woo, "Prophylactic alpha interferon treatment increases the therapeutic index of oncolytic vesicular stomatitis virus virotherapy for advanced hepatocellular carcinoma in immune-competent rats," Journal of Virology, vol.
Evolution of fitness in experimental populations of vesicular stomatitis virus.
The rVSV?G-LASV-GPC Vaccine is based on an attenuated strain of vesicular stomatitis virus that has been modified to express a Lassa fever virus protein that plays an essential role in establishing virus infection.
The collaboration is aimed at jointly developing a new generation oncolytic virus therapy platform and to investigate the company's lead candidate VSV-GP (Vesicular Stomatitis Virus (VSV) glycoprotein (GP)).
The experimental vaccine is based on a genetically modified and attenuated vesicular stomatitis virus (VSV), a virus that mainly affects cattle.
Ebola vaccines are also well underway in preclinical research, through non-replicating viral vectors platforms (chimpanzee adenovirus Ad3), viral-vectored vaccines (vesicular stomatitis virus, or modified vaccinia Ankara), recombinant adenovirus vector platform (Ad 26 & Ad 35), or adjuvanted virus-like particles.
They found that when the assembly of STAT1 chains was inhibited, type I interferons responsible for protecting against viruses such as vesicular stomatitis virus were unaffected, whereas type II interferons, which protect against bacterial infections such as listeria, no longer functioned effectively.
(Profectus), a clinical stage biopharmaceutical company focused on the development of novel vaccine candidates for serious chronic infections, has entered into a research collaboration agreement with the PATH Malaria Vaccine Initiative (MVI) to conduct proof-of-concept study with its proprietary, recombinant vesicular stomatitis virus (rVSV) vector technology as a preventative malaria vaccine.
It can also be used to quickly distinguish between FMD and vesicular stomatitis, an animal disease with similar symptoms that occasionally crops up in the United States.

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