VLDLR

(redirected from very low-density lipoprotein receptor)

VLDLR

A gene on chromosome 9p24 that encodes a cell surface protein  involved in receptor-mediated endocytosis of very low-density lipoprotein (VLDL), and transports it into cells by endocytosis. Internalisation of the receptor-ligand complex requires clustering into clathrin-coated pits.

Molecular pathology
VLDLR mutations cause VLDLR-associated cerebellar hypoplasia.
References in periodicals archive ?
Discovered in 1922, the Very Low-Density Lipoprotein Receptor (VLDLR) protein has long been known to facilitate the migration of neurons in the developing brain and to play a role in cholesterol uptake.
Discovered in 1922, the Very Low-Density Lipoprotein Receptor (VLDLR) protein, has long been known to facilitate the migration of neurons in the developing brain and to play a role in cholesterol uptake.