Verruciform xanthoma is a benign proliferation most commonly occurring in the oral cavity.
(93,95) The absence of cytologic atypia or koilocytosis in verruciform xanthoma speaks against condyloma acuminatum, and the presence of xanthomatous cells excludes verrucous carcinoma.
Amongst these are relatively rare entities such as bowenoid papulosis, epidermolytic acanthoma, and verruciform xanthoma, which are underrecognized by surgical pathologists.
Nikai, "Verruciform xanthoma of the oral mucosa: a clinicpathological study with immunohistochemical findings relating to pathogenesis," Virchows Archiv A Pathological Anatomy and Histopathology, vol.
Li, "Verruciform xanthoma of the oral cavity: clinicopathological study relating to pathogenesis," APMIS, vol.
Garcia-Perales, "Verruciform xanthoma of the esophagus," Human Pathology, vol.
Paik, "Verruciform xanthoma arising in the mid esophagus," Digestive Endoscopy, vol.
Setting the diagnosis of FEH is important to ensure differential diagnosis from other more serious conditions including inflammatory fibrous hyperplasia, inflammatory papillary hyperplasia, verruciform xanthoma
, verrucous carcinoma, condyloma acuminatum, Cowden's Syndrome, Crohn's disease, and Amyloidosis.
Moyal-Barracco, "Vulvar verruciform xanthoma
: ten cases associated with lichen sclerosus, Lichen Planus, or other conditions," Archives of Dermatology, vol.
Such lesions are collectively referred to as keratinizing lesions of the oral cavity and are inclusive of reactive lesions (frictional keratosis, smokeless tobacco induced keratosis, nicotine stomatitis, hairy tongue, hairy leukoplakia), immune mediated lesions (lichen planus, discoid lupus erythematosus, graft versus host disease), pre-neoplastic and neoplastic diseases (actinic cheilosis, leukoplakia, proliferative verrucous leukoplakia, verrucous carcinoma, squamous cell carcinoma), and infections (squamous cell papilloma, verruca vulgaris, condyloma accuminatum, molluscum contagiosum and verruciform xanthoma
It is widely assumed that the Human papilloma Virus (HPV) is an etiologic factor of papillomas.1 The lesion may look wart-like or cauliflower like and may be difficult to differentiate clinically from verruca vul- garis, condyloma acuminatum, verruciform xanthoma
or focal epithelial hyperplasia.2,3
These are either benign or reactive, for example, papilloma, verruca vulgaris, fibroepithelial polyp and verruciform xanthoma
, which usually present with little diagnostic difficulty.