One of the most important trichothecene, verrucarin J produced by several genera of fungi that may contaminate foods of both human and animal.
5 mg/kg body weight) of verrucarin J according to L[D.
In the present study, the level of thiobarbituric acid reactive substances, which are marker for lipid peroxidation (Frankel 1984), has increased after administration of verrucarin J in mice (Figure 1).
The previous data indicated that verrucarin J may act as prooxidant (activate the peroxide oxidation).
In the present study, the urea level (Figure 4) was increased after administration of verrucarin J in mice, the possible reasons were increase of renal insufficiency, nephritis, acute and chronic renal failure or as a result of increasing nitrogen metabolism associated with diminished renal blood flow or impaired renal function dehydration.
From the data in Tables 3 & 4 and Figure 5, it is shown that the creatinine level was increased after intraperitoneally injection of verrucarin J in mice.
Deoxynivalenol, T-2 toxin, and verrucarin A (Sigma Chemical Co.
Mice intranasally exposed to deoxynivalenol, T-2, and verrucarin A, which are type A, type B, and macrocyclic trichothecenes, respectively, using doses of equivalent to one-third to one-fifth of L[D.