verapamil


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.

verapamil

 [vĕ-rap´ah-mil]
a calcium channel blocking agent used as the hydrochloride salt as a coronary vasodilator in the treatment of angina pectoris and of hypertension and the treatment and prophylaxis of supraventricular tachyarrhythmias.

verapamil

(və-răp′ə-mĭl′)
n.
A calcium channel blocker drug, C27H38N2O4, that acts as a coronary vasodilator and is used in its hydrochloride form to treat hypertension and certain cardiac arrhythmias.

verapamil

Cardiology A CCB antiarrhythmic that slows transmission of impulses across the AV node and supresses the sinus node's intrinsic rhythm Indications Tachycardial supraventricular arrhythmias–eg, paroxysmal supraventricular tachycardia, A Fib with tachyarrhythmias, atrial flutter with rapid conduction, and is the parenteral emergency drug of choice Adverse effects Constipation, slowed AV conduction and sinus node automaticity, peripheral edema; it is a standard agent for managing HTN, especially in Pts with angina; it improves pain linked to obstructive cardiomyopathy, and prevents migraines Contraindications Severe left ventricular dysfunction, hypotension, sick sinus syndrome, 2º or 3º AV block, WPW, heart failure, or in Pts with accessory bypass tracts, WPW syndrome, peripheral edema; caution in renal failure. See Calcium channel blocker, Therapeutic drug monitoring. Cf Beta blocker.

verapamil

A calcium channel blocker drug used to correct irregularities in the heart beat. There is evidence that verapamil and other calcium channel blockers are anti-atherogenic and can prevent recurrent narrowing of arteries, such as the coronary arteries after these have been widened by CORONARY ANGIOPLASTY. The drug is on the WHO official list. Brand names are Cordilox, Securon, Univer and Vertab SR. Formulated with trandolapril it is marketed as Tarka.
References in periodicals archive ?
There are no additional benefits of using calcium channel blocker (Verapamil) with nitrate.
Consistent with AGC mRNA measurements, increased levels of AGC protein were also observed in cells exposed to mechanical stress and verapamil compared to mechanical stress alone.
Clozapine-induced supraventricular tachycardia and its treatment with verapamil. Indian J Psychol Med 2015;37:358-9.
Goadsby, "Electrocardiographic abnormalities in patients with cluster headache on verapamil therapy," Neurology, vol.
Agrawal et al., "In vivo anticancer synergy mechanism of doxorubicin and verapamil combination treatment is impaired in BALB/c mice with metastatic breast cancer," Experimental and Molecular Pathology, vol.
3) The drug that contained different concentrations of P-gp inhibitor verapamil hydrochloride was used for the perfusion experiment on ileum to study the influence of verapamil hydrochloride upon drug absorption.
A Report of Brugada Syndrome Presenting with Cardiac Arrest Triggered by Verapamil Intoxication.
Prevention and treatment of keloids with intralesional verapamil. Dermatology 2002;204(1):60-2.
Once stabilized, the patient was treated for verapamil overdose and severe metabolic acidosis according to our institutional guidelines for calcium channel blocker overdose.
In addition, the ER values were significantly lower in the groups treated with verapamil than in the groups without verapamil, indicating that P-gp was participated in the transport of brucine and strychnine.
The minimum toxic doses were determined to be 0.03 g for amlodipine, 0.16 g for verapamil, and 0.2 g for nifedipine by considering the lowest reported toxic doses for adults (8).