In other instances, termination of pregnancy may be requested when the implications of the investigations are less clear, for examplea foetus with mild cerebral ventriculomegaly
. After termination of pregnancy, most parents would like to know if the prenatal prediction was accurate and its implications for future pregnancies.
These abnormalities included ventriculomegaly
, subcortical calcifications, cortical malformations, and decreased brain volume.
A subsequent obstetrical ultrasound at 32 weeks' gestation revealed numerous fetal anomalies that were confined to the central nervous system: microcephaly (head circumference below the second percentile), moderate ventriculomegaly
, decreased transcerebellar diameter (below the second percentile), blurring of the brain structures, and numerous calcifications.
In animal studies, an increasing degree of ventriculomegaly
is associated with more marked thinning of the cerebral cortex .
When symptomatic ventriculomegaly
or hydrocephalus is identified, treatment should be seriously considered.
Their results revealed that LKSL treatment alleviated subarachnoid fibrosis, delayed the progress of chronic hydrocephalus, and prevented ventriculomegaly
formation by suppressing TSP-1-mediated TGF-[beta] signaling pathway.
Postmortem examination reveals microcephaly, ventriculomegaly
, extensive brain atrophy, intracranial calcifications, cerebellar agenesis, cataracts, ocular calcifications, redundant scalp tissue, and multiple joint contractures.
may be diagnosed antenatally or postnatally with various imaging modalities.
Treatment of post-hemorrhagic ventriculomegaly
in the preterm infant: Use of the subcutaneous ventricular reservoir.
Imaging will often be unremarkable, with little or no basal enhancement and no ventriculomegaly
, sometimes even atrophy.
Ventricular access was most commonly attained through a right-sided approach (unless asymmetric left-sided ventriculomegaly
was present, in which case a left-sided approach was preferred).
Visualization of the brain (Figure 5) was limited to the inferior portions of the temporal and occipital lobes, but ventriculomegaly
was noted, as was diffuse T2 prolongation throughout the visualized portions of white matter.