The Phase IV, 52-week, single-arm, open-label PROVE-HF trial showed that treatment with Entresto significantly improved levels of an important biomarker shown to be associated with prognosis of clinical outcomes in HFrEF, N-terminal pro-B-type natriuretic peptide (NT-proBNP), which was linked for the first time to significant improvements in left ventricular remodeling
and echocardiographic measures of cardiac structure and function,,.
Studies have showed that, the formation of vulnerable plaque and occurrence of coronary event are closely related to left ventricular remodeling
. Intravascular unltrasound can recognize the property of coronary artery lesion and vascular wall structure of old CHD patients, and judge remolding property of plaque and plaque property so as to predict left ventricular remodeling
.10,11 Early identification of the nature of coronary atherosclerotic plaque and its relationship with left heart remodeling is essential for early intervention in the treatment of coronary heart disease.
It appears to be the major factor influencing the pattern of left ventricular remodeling
, particularly in the concentric type.
Age-related left ventricular remodeling
and associated risk for cardiovascular outcomes: The Multi-Ethnic Study of Atherosclerosis.
Left ventricular remodeling
in heart failure: Current concepts in clinical significance and assessment.
Detrimental ventricular remodeling
in patients with congenital complete heart block and chronic right ventricular apical pacing.
Ma et al16 reported that ivabradine enhance myocardial performance, left ventricular function and ventricular remodeling
and even survival in rodent heart failure, including ventricular fibrillation, myocardial infarction, stable angina, and hypertension-induced cardiomyopathy16.
Suselbeck et al., "Intracoronary delivery of injectable bioabsorbable scaffold (IK-5001) to treat left ventricular remodeling
after ST-elevation myocardial infarction: a first-in-man study," Circulation: Cardiovascular Interventions, vol.
The association of Gal-3 and ventricular remodeling
is plausible since fibrosis and inflammatory responses are pivotal processes in maladaptive cardiac remodeling .
AMI is the leading cause of death worldwide, and those who survive are at higher risk for adverse ventricular remodeling
and heart failure .
The echocardiogram (Figure 1; Table 1) documented left ventricular dilation in both systole and diastole, reduced fractional shortening (14%) and ejection fraction (30%), and an increased E-point septal separation (14.7mm), which suggested systolic myocardial failure with eccentric left ventricular remodeling
. Also, the left atrium (LA) dimension was increased, as was the LA/aorta ratio (1.83).