Cavernosography is performed only when a veno-occlusive
problem has been demonstrated or is suspected.
The vascular changes are usually diffuse and interfere with blood supply to the penis and with a veno-occlusive
mechanism of the corpora cavernosa (Kaufman, Hatzichristou, Mulhall, Fitch, & Goldstein, 1994).
Decreased portal vein flow velocity and reversal of the flow direction is seen in the terminal stage of hepatic cirrhosis and a few other conditions such as hepatic sinusoidal obstruction (hepatic veno-occlusive
disease), arterioportal fistula, extrahepatic portal vein thrombosis, and hepatic venous outflow obstruction (6).
The patient had mild veno-occlusive
disease of the liver that eventually resolved, and several (4-5) episodes of CMV viremia, but no evident GVHD throughout his course.
(Nasdaq:GENT), Villa Guardia (COMO), Italy, has announced that its Marketing Authorization Application (MAA) seeking approval of Defibrotide for the prevention and treatment of hepatic veno-occlusive
disease (VOD) following stem-cell transplantation has been accepted for review by the European Medicines Agency (EMA).
Etiology from most prevalent to least was as following: congenital heart diseases (27%), chronic thromboembolic pulmonary hypertension (24%), connective tissue diseases-scleroderma (14%), idiopathic PAH (8%), diastolic dysfunction (3%), pulmonary disease (3%), pulmonary veno-occlusive
disease (2%), hepatopulmonary hypertension (1%), and HIV-infection associated PAH (1%).
In another study (Steenkamp et al., 2000), 20 children were identified with hepatic veno-occlusive
disease, probably due to the administration of HMPs; 9 children died.
Pharmacokinetics of busulfan: correlation with veno-occlusive
disease in patients undergoing bone marrow transplantation.
Consumption of these compounds has been associated with hepatic veno-occlusive
disease and death, including one neonatal death after intrauterine exposure following maternal consumption of herbal teas during pregnancy (5).
Safety and efficacy of epoprostenol therapy in pulmonary veno-occlusive
disease and pulmonary capillary hemangiomatosis.
RESULTS: Out of twelve patients, eight patients had normal Doppler sonographic findings; two had signs of veno-occlusive
dysfunction and two had features of arterial insufficiency.