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Evaluating the effects of 14-day oral vedaprofen and tolfenamic acid treatment on renal function, hematological and biochemical profiles in healthy cats.
The cats were divided into four treatment groups: vedaprofen only, tramadol only, vedaprofen plus tramadol and placebo.
Cats treated with vedaprofen and tramadol together did not require rescue analgesia and proved to be the most effective option evaluated.
Non-steroidal anti-inflammatory drugs such as carprofen, dipyrone, eltenac, flunixin, ketoprofen, meloxicam, phenylbutazone and vedaprofen were among those at the centre of the study, along with the diuretic furosemide.
Perioperative administration of vedaprofen, tramadol or their combination does not interfere with platelet aggregation, bleeding time and biochemical variables in cats.
Studies investigating vedaprofen in dogs and horses found that it is a safe and satisfactory NSAID to prevent the acute release of inflammatory mediators, while providing excellent gastrointestinal and renal tolerance in these especies (BERGMAN et al.
The dogs were randomly assigned to one of the three groups as follows; vedaprofen (a) at 0.
During all period of measurements, the pain scores in the vedaprofen, carprofen and ketoprofen groups were almost identical.
Despite vedaprofen was well tolerated by most of the dogs with acute and chronic musculosketal pain (NELL et al.
Significant differences on pain scores and cortisol concentrations among groups were not detected during the 24 hours after surgery and, on the basis of these results, vedaprofen given prior to ovariohysterectomy provides similar levels and duration of postoperative analgesia as that of carprofen or ketoprofen in dogs.
Vedaprofen provides satisfactory postoperative analgesia that appears to be equal to that of carprofen and ketoprofen in dogs undergoing ovariohysterectomy.
Second intention skin wound healing in equines under vedaprofen treatment.