and Atracurium are two muscle relaxants that come close to fulfil most of the above criteria.
The injection consisted of a sedative midazolam, a muscle-relaxer vecuronium
bromide and potassium chloride.
But Justice Sonia Sotomayor issued a blistering dissent, recounting details from a recent state court trial of a case brought by inmates contesting Tennessee's execution drugs -- midazolam as a sedative, the muscle-relaxer vecuronium
bromide and then potassium chloride to stop the heart.
In contrast to neostigmine, sugammadex, just encapsulating aminosteroidal NMBA (rocuronium, vecuronium
, pancuronium, pipecuronium), is equally efective in inhalative and intravenous anaesthesia (47).
A study conducted by Dupuis et al (29) found vecuronium
better than pancuronium for reduction of shivering because vecuronium
was not shown to increase myocardial work and was associated with fewer complications.
GA was induced with propofol 120mg, vecuronium
8mg, and glycopyrolate 0.2mg and the patient was mask-ventilated for 3 minutes with 100% oxygen and 7.0 Vol% Sevoflurane.
However, the amount of vecuronium
consumed by patients who were administered sugammadex was identified as 56 (IQR: 48-63) mg, while the amount of vecuronium
consumed by patients who were administered neostigmine was identified as 50 (IQR: 47-55) mg.
He received three injections consisting of three drugs: potassium chloride to stop his heart, midazolam to render him unconscious and vecuronium
bromide to stop him from breathing.
Sugammadex is a novel agent for the reversal of the neuromuscular blockade that provided by rocuronium and vecuronium
. It acts differently from anticholinesterases and can reverse even profound blocks induced with vecuronium
Rocuronium bromide, ORG-9246, a newer nondepolarizing muscle relaxant with quick onset and intermediate duration of action has one-sixth of potency of vecuronium
, which was introduced in the 1990s.
The other Pfizer products the drugmaker said it will block from use in executions are pancuronium bromide, potassium chloride, idazolam, hydromorphone, rocuronium bromide and vecuronium