Aims and Objectives: This study was conducted to understand the role of N-methyl-D-aspartate (NMDA) receptor in modulating vasosensory reflex responses evoked by Mesobuthus tumulus venom.
KEY WORDS: N-methyl-D-aspartate Receptor; 2-amino 5-phosphonovaleric Acid; Nociception; Vasosensory Reflexes; Cardiorespiratory Changes
8] The venom-induced vasosensory reflex responses lasts longer than the other nociceptive agonists (capsaicin/anandamide/[alpha] [beta]Me-ATP)-induced responses.
3]) receptor, and B1-kinin receptor is well established in the venom-induced vasosensory reflex responses.
7] Therefore, this concentration was used as a tool for the elicitation of vasosensory reflex responses in this study.
In our earlier reports, BT venom-induced vasosensory reflex responses altering cardiorespiratory parameters have been demonstrated.
The present results demonstrate the involvement of extracellular inflammatory mediators (bradykinin and PGs) in producing nociceptive vasosensory reflexes modulating the 5-[HT.
Vasosensory responses elicited by Indian red scorpion venom last longer than capsaicin-induced responses.
Buthus tamulus venom-induced vasosensory reflexes are mediated through efferent pathways in sympathetic and vagal parasympathetics.
B1-kinin receptors modulate Mesobuthus tumulus venom-induced vasosensory reflex responses in anesthetized rats.