Hart," Mechanism of vasorelaxation
and role of endogenous hydrogen sulfide production in mouse aorta," Naunyn-Schmiedebergs Archives of Pharmacology, vol.
In context of CAD, the studies introduced that Ucn-2 induces the vasorelaxation
of coronary arteries independent from endothelial cell activation (9), plasma Ucn is elevated in acute myocardial infarction, and Ucn-1, Ucn-2 may play a protective in ischemia-reperfusion injury (10, 11, 30).
in hypertensive rats.
in inbred mice is associated with alterations in both nitric oxide and super oxide pathways.
(21), (22) The properties possessed by resveratrol are said to include the "modulation of vascular dilator tone, regulation of local cell growth, and protection of the vessel from injurious consequences of platelets and cells circulating in blood," as well as "defense against ischemicreperfusion injury, promotion of vasorelaxation
, protection and maintenance of intact endothelium, antiatherosclerotic properties, inhibition of low-density lipoprotein oxidation, and suppression of platelet aggregation." (24) Additionally, expanding evidential support has correlated the constitutive expression of nitricoxide with a cardio-protective role.
C-reactive protein-induced in vitro vasorelaxation
is an artifact caused by the presence of sodium azide in commercial preparations.
[AT.sub.2]R located on smooth muscle of rat aortic rings mediated vasorelaxation
via stimulation of B2 receptors by bradykinin, which in turns results in the activation of the NO-cGMP pathway, vasodilator cyclooxygenase product(s), and voltage-dependent and Ca+-activated large-conductance K+ channels (Fukada et al., 2005).
This decreased cardiac output could be due to shifting of blood volume from the central circulation to the splanchnic circulation or to the vasorelaxation
of the sphanchnic vessels.
In animal models, high-glucose induced neointimal formation in a carotid arterial balloon injury model (7), impaired endothelium-dependent vasorelaxation
(12), and enhanced the production of vascular cell adhesion molecules (13).
Aortic miR-204 was upregulated, with impaired endothelium-dependent vasorelaxation
and increased vascular inflammation.
Sulfur dioxide derivatives improve the vasorelaxation
in the spontaneously hypertensive rat by enhancing the vasorelaxant response to nitric oxide.