The inhibitors of AC and GC (ODQ and SQ22536) were used to explore whether there was an involvement of the cAMP and cGMP pathway in the vasodilative action of DG.
In the present study, we demonstrated the vasodilative effect of DG on the diagonal branch of a LAD artery of the porcine heart.
In conclusion, our present study for the first time demonstrated the vasodilative effect of DG on a porcine LAD artery.
In addition, underlying mechanisms of the vasodilative effect of ginseng remain elusive.
Vasodilative effect of TGS was blocked by inhibitors of NO, [PGI.sub.2].
To understand whether these vasodilators are involved in the vasodilative action of TGS in rat hearts, we used inhibitors of NO, [PGI.sub.2], EDHF, sGC and HO to perfuse hearts before TGS (50 mg/l) treatment and examined if inhibition of these mediators could block the vasodilative effect of TGS.
However, there is not direct evidence showing the vasodilative effect of ginsenosides on coronary artery.
Verapamil is a calcium channel blocker with vasodilative action and negative inotropic effect on the heart (Urquhart et al., 1984), which reduce oxygen consumption of the heart but may not benefit the systolic and diastolic functions of ischemic hearts (Kolar et al., 1990).
These results led us to examine the vasodilative effect of perillaldehyde.
Vasodilative effect of perillaldehyde on isolated aortic rings
L-NAME (0.1 mM) or various inhibitors (1 mM propranolol, 0.1 mM theophylline, 5 mM tetraethylammonium chloride (TEA), and 10 [micro]M glibenclamide) were pre-treated for 60 and 10 min, respectively, and then the vasodilative effect of perillaldehyde was examined on the endothelium-intact aorta.
1B shows that perillaldehyde caused a dose-dependent vasodilatation in PG[F.sub.2[alpha]]- or NE-induced contraction, although the vasodilative effects of perillaldehyde at 0.3 mM differed between the two.