vaso-occlusive crisis


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Related to vaso-occlusive crisis: sickle-cell disease, acute chest syndrome, Sickle cell crisis

crisis

 [kri´sis] (pl. cri´ses) (L.)
1. the turning point of a disease for better or worse; especially a sudden change, usually for the better, in the course of an acute disease.
2. a sudden paroxysmal intensification of symptoms in the course of a disease.
addisonian crisis (adrenal crisis) the symptoms accompanying an acute onset or worsening of addison's disease: anorexia, vomiting, abdominal pain, apathy, confusion, extreme weakness, and hypotension; if untreated these progress to shock and then death.
aplastic crisis a sickle cell crisis in which there is temporary bone marrow aplasia.
blast crisis a sudden, severe change in the course of chronic granulocytic leukemia, characterized by an increased number of blasts, i.e., myeloblasts or lymphoblasts.
catathymic crisis an isolated, nonrepetitive act of violence that develops as a result of intolerable tension.
celiac crisis an attack of severe watery diarrhea and vomiting producing dehydration and acidosis, sometimes occurring in infants with celiac disease.
developmental crisis maturational crisis.
hemolytic crisis an uncommon sickle cell crisis in which there is acute red blood cell destruction with jaundice.
hypertensive crisis dangerously high blood pressure of acute onset.
identity crisis a period in the psychosocial development of an individual, usually occurring during adolescence, manifested by a loss of the sense of the sameness and historical continuity of one's self, confusion over values, or an inability to accept the role the individual perceives as being expected by society.
life crisis a period of disorganization that occurs when a person meets an obstacle to an important life goal, such as the sudden death of a family member, a difficult family conflict, an incident of domestic violence (spouse or child abuse), a serious accident, loss of a limb, loss of a job, or rape or attempted rape.
maturational crisis a life crisis in which usual coping mechanisms are inadequate in dealing with a stress common to a particular stage in the life cycle or with stress caused by a transition from one stage to another. Called also developmental crisis.
myasthenic crisis the sudden development of dyspnea requiring respiratory support in myasthenia gravis; the crisis is usually transient, lasting several days, and accompanied by fever.
oculogyric crisis a symptom of an acute dystonic reaction in which the person demonstrates a fixed gaze, usually upward; also, the uncontrollable rolling upwards of the eye. It can be a result of encephalitis or a reaction to antipsychotic medications.
salt-losing crisis see salt-losing crisis.
sickle cell crisis see sickle cell crisis.
tabetic crisis a painful paroxysm occurring in tabes dorsalis.
thyroid crisis (thyrotoxic crisis) see thyroid crisis.
vaso-occlusive crisis a sickle cell crisis in which there is severe pain due to infarctions in the bones, joints, lungs, liver, spleen, kidney, eye, or central nervous system.

vaso-occlusive crisis

Painful crisis Hematology A 'crisis' common in sickle cell anemia, in which 'sludged' sickled RBCs cause capillary stasis and infarction, and incapacitating musculoskeletal pain or 'referral'-type organ pain, hemoptysis, hematuria, melena, CNS Sx; VOCs occur at a rate of 0.8 episodes/yr in sickle cell disease, 1.0/yr in sickle-β-thalassemia, and 0.4/yr in HbSC-β thalassemia; this frequency is translated into a 'pain rate', a measure of disease severity that correlates with early death in Ps with sickling anemias Management High-dose methylprednisolone ↓ duration of painful crises; rebound attacks ↑ with discontinuation of steroids. See Hemolytic crisis, Sickle cell anemia.

vaso-occlusive crisis (in sickle cell disease)

Painful occlusions of blood vessels in bones, the chest, the lungs, or the abdomen in patients with sickle cell anemia. The syndrome is caused by sickling of blood cells in small blood vessels, with resulting infarction and tissue death. Synonym: sickle cell crisis
See also: crisis
References in periodicals archive ?
The primary objective of the EPIC study is to demonstrate that vepoloxamer reduces the duration of vaso-occlusive crisis, with the duration of crisis measured from the time a patient is randomised to the time at which the patient receives the last dose of parenteral opioid analgesic for the treatment of vaso-occlusive crisis prior to hospital discharge.
One of the most severe complications of sickle cell disease is vaso-occlusive crisis (VOC), which is typically characterised by excruciating, debilitating pain that occurs periodically throughout the life of a person with sickle cell disease.
Under the terms of the agreement, Pfizer will receive an exclusive worldwide license to GMI-1070 for vaso-occlusive crisis associated with sickle cell disease and for other diseases for which the drug candidate may be developed.
There are more than 75,000 hospitalizations per year associated with vaso-occlusive crisis in the U.
The main clinical feature of sickle cell disease is periodic painful vaso-occlusive crisis episodes, known as VOC or pain crises, which result in clinical complications, interruptions in patients' lives and cumulative irreversible damage that impacts the morbidity and mortality of patients.
It provides key support for the Company's clinical program in sickle cell disease, which is targeting treatment of vaso-occlusive crisis - the disease's main clinical feature.
One patent, US number 7,728,117, specifically covers GMI-1070, the Company's drug candidate now in clinical trials of patients with vaso-occlusive crisis of sickle cell disease.
The primary objective will be to demonstrate that ANX-188 reduces the duration of vaso-occlusive crisis in patients with sickle cell disease.
FDA Grants GMI-1070 Fast Track Designation for Treatment of Vaso-Occlusive Crisis of Sickle Cell Disease
It concludes that the trial supports the further evaluation of GMI-1070 for the treatment of sickle cell patients in vaso-occlusive crisis.
The new investment will be used to fund a Phase 2 trial of GlycoMimetics' lead drug candidate GMI-1070 in vaso-occlusive crisis of sickle cell disease.
GlycoMimetics' GMI-1070 targets vaso-occlusive crisis