vaso-occlusive crisis

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Related to vaso-occlusive crisis: sickle-cell disease, acute chest syndrome, Sickle cell crisis


 [kri´sis] (pl. cri´ses) (L.)
1. the turning point of a disease for better or worse; especially a sudden change, usually for the better, in the course of an acute disease.
2. a sudden paroxysmal intensification of symptoms in the course of a disease.
addisonian crisis (adrenal crisis) the symptoms accompanying an acute onset or worsening of addison's disease: anorexia, vomiting, abdominal pain, apathy, confusion, extreme weakness, and hypotension; if untreated these progress to shock and then death.
aplastic crisis a sickle cell crisis in which there is temporary bone marrow aplasia.
blast crisis a sudden, severe change in the course of chronic granulocytic leukemia, characterized by an increased number of blasts, i.e., myeloblasts or lymphoblasts.
catathymic crisis an isolated, nonrepetitive act of violence that develops as a result of intolerable tension.
celiac crisis an attack of severe watery diarrhea and vomiting producing dehydration and acidosis, sometimes occurring in infants with celiac disease.
developmental crisis maturational crisis.
hemolytic crisis an uncommon sickle cell crisis in which there is acute red blood cell destruction with jaundice.
hypertensive crisis dangerously high blood pressure of acute onset.
identity crisis a period in the psychosocial development of an individual, usually occurring during adolescence, manifested by a loss of the sense of the sameness and historical continuity of one's self, confusion over values, or an inability to accept the role the individual perceives as being expected by society.
life crisis a period of disorganization that occurs when a person meets an obstacle to an important life goal, such as the sudden death of a family member, a difficult family conflict, an incident of domestic violence (spouse or child abuse), a serious accident, loss of a limb, loss of a job, or rape or attempted rape.
maturational crisis a life crisis in which usual coping mechanisms are inadequate in dealing with a stress common to a particular stage in the life cycle or with stress caused by a transition from one stage to another. Called also developmental crisis.
myasthenic crisis the sudden development of dyspnea requiring respiratory support in myasthenia gravis; the crisis is usually transient, lasting several days, and accompanied by fever.
oculogyric crisis a symptom of an acute dystonic reaction in which the person demonstrates a fixed gaze, usually upward; also, the uncontrollable rolling upwards of the eye. It can be a result of encephalitis or a reaction to antipsychotic medications.
salt-losing crisis see salt-losing crisis.
sickle cell crisis see sickle cell crisis.
tabetic crisis a painful paroxysm occurring in tabes dorsalis.
thyroid crisis (thyrotoxic crisis) see thyroid crisis.
vaso-occlusive crisis a sickle cell crisis in which there is severe pain due to infarctions in the bones, joints, lungs, liver, spleen, kidney, eye, or central nervous system.

vaso-occlusive crisis

Painful crisis Hematology A 'crisis' common in sickle cell anemia, in which 'sludged' sickled RBCs cause capillary stasis and infarction, and incapacitating musculoskeletal pain or 'referral'-type organ pain, hemoptysis, hematuria, melena, CNS Sx; VOCs occur at a rate of 0.8 episodes/yr in sickle cell disease, 1.0/yr in sickle-β-thalassemia, and 0.4/yr in HbSC-β thalassemia; this frequency is translated into a 'pain rate', a measure of disease severity that correlates with early death in Ps with sickling anemias Management High-dose methylprednisolone ↓ duration of painful crises; rebound attacks ↑ with discontinuation of steroids. See Hemolytic crisis, Sickle cell anemia.

vaso-occlusive crisis (in sickle cell disease)

Painful occlusions of blood vessels in bones, the chest, the lungs, or the abdomen in patients with sickle cell anemia. The syndrome is caused by sickling of blood cells in small blood vessels, with resulting infarction and tissue death. Synonym: sickle cell crisis
See also: crisis
References in periodicals archive ?
In prior Phase 1 clinical evaluation in healthy volunteers and a pilot study in sickle cell patients not undergoing vaso-occlusive crisis at the time of dosing, GMI-1070 demonstrated encouraging safety and pharmacokinetic data, consistent with GlycoMimetics' preclinical studies of the compound.
GlycoMimetics is initially developing GMI-1070 for the treatment of vaso-occlusive crisis of sickle cell disease.
GMI-1070 appears to have interesting potential as a new treatment for vaso-occlusive crisis in sickle cell patients.
These comorbidities include vaso-occlusive crisis, Acute Chest Syndrome, leg ulcers and pediatric and adult stroke.
Phase II trials are also planned for vaso-occlusive crisis and leg ulcers secondary to SCD as well as for preventing delayed graft function following kidney transplantation.
The candidate is a rationally designed carbohydrate mimic (or "glycomimetic") that has been shown to inhibit inflammation in several animal models of disease, including vaso-occlusive crisis of sickle cell disease.
The study described in the presentation concludes that GMI-1070 can significantly improve outcomes - including survival - when animals are dosed after a vaso-occlusive crisis is well underway.
Vepoloxamer is being tested in a pivotal Phase 3 study called EPIC for the treatment of vaso-occlusive crisis in patients with sickle cell disease and in a Phase 2 study to evaluate whether vepoloxamer improves the effectiveness of recombinant tissue plasminogen activator therapy in patients with acute limb ischemia.
a privately held company developing a new class of glycobiology-based therapies for a broad range of indications, today announced it has initiated a Phase 1 clinical trial for GMI-1070, its lead drug candidate for the treatment of vaso-occlusive crisis of sickle cell disease.